Evaluate the safety and efficacy of Inaticabtagene autoleucel combined with autologous hematopoietic stem cell transplantation in adolescents or adults with MRD-positive initial complete remission in B-cell acute lymphoblastic leukemia.
Evaluate the safety and efficacy of Inaticabtagene autoleucel combined with autologous hematopoietic stem cell transplantation in adolescents or adults with MRD-positive initial complete remission in B-cell acute lymphoblastic leukemia.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
CNCT19 combined with autologous hematopoietic stem cell transplantation,Dose: (0.5 -2)x 10\^6/kg CNCT19 Cell Injection via intravenous infusion.
National Institute of Hematology, Chinese Academy of Medical Sciences
Tianjin, Tianjin Municipality, China
RECRUITINGRelapse-Free Survival
The time from the start of infusion of Inaticabtagene autoleucel until the diagnosis of relapse or any death (whichever comes first).
Time frame: From autologous hematopoietic stem cell transplantation to 2 years after transplantation
Overall survival rate
Time frame: From autologous hematopoietic stem cell transplantation to 2 years after transplantation
Cumulative recurrence rate
Time frame: From autologous hematopoietic stem cell transplantation to 2 years after transplantation
MRD negativity rate
Time frame: 28 days after the first CAR-T cell reinfusion
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