Caffeine, CYPA12 and Resistance Exercise

Alberto Pérez-López60 enrolled

Overview

Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the acute effects of caffeine on this type of exercise. Objectives: The present study aims to analyze the effects of acute caffeine intake on muscular strength, power, and endurance performance according to CYP1A2 polymorphism in men and women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

CYP1A2 Polymorphism Caffeine and Resistance Exercise

Interventions

CaffeineDIETARY_SUPPLEMENT

Acute caffeine intake (3 mg/kg)

PlaceboDIETARY_SUPPLEMENT

Placebo (3 mg/kg maltodextrin)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between ≥ 18 and ≤ 35 years. * Body mass index (BMI) lower than 25 kg/m². * Physically active subjects (≥150 min/week of moderate exercise). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise. * Participants capable of performing the tests. Exclusion Criteria: * History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism. * Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study. * Body mass index (BMI) ≥ 25 kg/m². * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. * Performing strenuous exercise within 48 hours prior to the tests. * Failing to replicate the same food intake on the two experimental days. * Consuming caffeine after 6 PM on the day prior to training or testing.

Locations (2)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

RECRUITING

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

RECRUITING

Outcomes

Primary Outcomes

cyp1a2 polymorphism

Using saliva sample and PCR

Time frame: Before the beginning of the trial

Mean velocity at different %1RM

Measuring bar mean velocity desplacement during bench press and back squat exercises.

Time frame: Through study completion, an average of 2 weeks

Peak velocity at different %1RM

Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.

Time frame: Through study completion, an average of 2 weeks

Mean power output at different %1RM

Measuring during bench press and back squat exercises.

Time frame: Through study completion, an average of 2 weeks

Peak power output and time to reach peak power output at different %1RM

Measuring during bench press and back squat exercises.

Time frame: Through study completion, an average of 2 weeks

Number of repetitions performed in 1 set at 65%1RM until task failure

In bench press and back squat exercises

Time frame: Through study completion, an average of 2 weeks

Bar velocity deplacement performed in 1 set at 65%1RM until task failure

In bench press and back squat exercises

Time frame: Through study completion, an average of 2 weeks

Power output generated in 1 set at 65%1RM until task failure

In bench press and back squat exercise

Central Contacts

Alberto Pérez-López, PhD

CONTACT

34 918854537 alberto.perezl@uah.es

Data from ClinicalTrials.gov

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Secondary Outcomes

Mood state (tension, depression, anger, vigor, fatigue and confusion)

Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question: How do you feel at this moment? to assess six scales: tension, depression, anger, vigor, fatigue and confusion.

Time frame: Through study completion, an average of 2 weeks

Adverse effects

perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort

Time frame: Through study completion, an average of 2 weeks

handgrip and isometric mid-thigh pull tests

N generated

Time frame: Through study completion, an average of 2 weeks

Vertical Jump (cm)

Time frame: Through study completion, an average of 2 weeks

Vertical Jump (power)

Time frame: Through study completion, an average of 2 weeks