Caffeine, CYPA12 and Resistance Training

Alberto Pérez-López48 enrolled

Overview

Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the prolonged effects of caffeine on this type of exercise. Objectives: The present study aims to analyze the prolonged effects of caffeine intake on neuromuscular adaptations to resistance training according to CYP1A2 polymorphism in men and women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

CYP1A2 Polymorphism Caffeine and Resistance Training

Interventions

Caffeine and Resistance trainingDIETARY_SUPPLEMENT

Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program.

Placebo and Resistance trainingDIETARY_SUPPLEMENT

Acute placebo intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between ≥ 18 and ≤ 35 years. * Body mass index (BMI) lowe than 25 kg/m². * Physically active subjects (≥ 150 min/week of moderate exercise). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise. * Participants capable of performing the tests. Exclusion Criteria: * History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism. * Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study. * Body mass index (BMI) ≥ 25 kg/m². * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. * Performing strenuous exercise within 48 hours prior to the tests. * Failing to replicate the same food intake on the two experimental days. * Consuming caffeine after 6 PM on the day prior to training or testing.

Locations (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

RECRUITING

Outcomes

Primary Outcomes

Mean velocity at different %1RM

Measuring bar mean velocity desplacement during bench press and back squat exercises.

Time frame: Through study completion, an average of 12 weeks

Peak velocity at different %1RM

Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises.

Time frame: Through study completion, an average of 12 weeks

Mean power output at different %1RM

Measuring during bench press and back squat exercises.

Time frame: Through study completion, an average of 12 weeks

Peak power output and time to reach peak power output at different %1RM

Measuring during bench press and back squat exercises.

Time frame: Through study completion, an average of 12 weeks

Number of repetitions performed at 65%1RM until task failure

In bench press and back squat exercises

Time frame: Through study completion, an average of 12 weeks

Bar velocity deplacement performed in 1 set at 65%1RM until task failure

In bench press and back squat exercises

Time frame: Through study completion, an average of 12 weeks

Power output generated in 1 set at 65%1RM until task failure

In bench press and back squat exercise

Time frame: Through study completion, an average of 12 weeks

Resting Metabolic Rate (RMR)

Kcal at rest using a metabolic chart.

Central Contacts

Alberto Pérez-López, PhD

CONTACT

918854537 alberto.perezl@uah.es

Data from ClinicalTrials.gov

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Secondary Outcomes

Fat-free mass

Using electrical bioimpedance and untrasound in the quadriceps muscle

Time frame: Through study completion, an average of 4 weeks

Fat mass

Using electrical bioimpedance (kg and % of body mass)

Time frame: Through study completion, an average of 12 weeks

Physical activity (METs-min/wk)

Using IPAQ

Time frame: Through study completion, an average of 12 weeks

Dietary (g/kg of macronutrients)

Using a 24-total recall

Time frame: Through study completion, an average of 12 weeks

Mood state

Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question;How do you feel at this moment?; to assess six scales: tension, depression, anger, vigor, fatigue and confusion.

Time frame: Through study completion, an average of 12 weeks

Adverse effects

Adverse effects. perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort.

Time frame: Through study completion, an average of 12 weeks