Local LevoBupivacaine for Pain Relief After Endoscopic Submucosal Dissection for Esophageal Lesions

Inclusion Criteria: * Patients age ≥18 years at time of consent * Visible lesion in the esophagus, minimum diameter of the lesion ≥20 mm * Scheduled for esophageal ESD * Informed consent Exclusion Criteria: * Presence of multiple lesions requiring two or more separate endoscopic resections * History of esophageal surgery other than fundoplications * History of esophageal ablation therapy * History of radiotherapy of the esophagus * Esophageal varices * Prior endoscopic resection in the same area * Uncontrolled coagulopathy * Severe medical comorbidities precluding endoscopy * Allergy to LB or other amide-type local anaesthesia * Current regular use of opioids * Other aetiology causing pain similar to post-ESD pain * Inability to assess pain due to severe psychiatric or neurological disease * Insufficient command of Dutch language * Brugada syndrome * Incapacitated patients