The goal of this case-control study is to investigate glucose brain metabolism in people with multiple sclerosis and age- and sex-matched healthy controls. The main questions it aims to answer are: * How does brain glucose metabolism in people with multiple sclerosis compare to age- and sex-matched healthy controls? * How is the brain glucose metabolism of people with multiple sclerosis associated with disease severity? Participants will come in for testing lasting approximately three hours and undergo deuterium metabolic imaging, physical function test, cognitive function test, and answer survey.
Study Type
OBSERVATIONAL
Enrollment
20
No delivered intervention.
Aarhus University
Aarhus C, Denmark
RECRUITINGlactate to glx ratio
Brain deuterium metabolic imaging determined lactate to glx ratio
Time frame: 2 hours from enrollment to end of assessment
Six-minute walk test
Measure of walking capacity as meters walking in six minutes
Time frame: 3 hours from enrollment to end of assessment
25 meter walk test
Maximal and usual walking speed over 25 feet including a 3 m measurement
Time frame: 3 hours from enrollment to end of assessment
Six-spot-step-test
Fastes time to kick six block away from six markings on the floor approximatly 1 meter from another in a zig-zag patteren.
Time frame: 3 hours from enrollment to end of assessment
Handgrip strength
Handgrip dynamometry
Time frame: 3 hours from enrollment to end of assessment
5-sit-to-stand
Time to perform five sit to stand.
Time frame: 3 hours from enrollment to end of assessment
Processing speed - Selective reminding test
Symbol digit modality test, number of symbols translated in 90 s
Time frame: 3 hours from enrollment to end of assessment
Memory function - Symbol digit modality test
Symbol digit modality test * Short term memory * consistence short term memory * long-term memory
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 3 hours from enrollment to end of assessment
Glukose level
From blood sample
Time frame: 3 hours from enrollment to end of assessment
Lactat level
From blood sample
Time frame: 3 hours from enrollment to end of assessment
Glucose uptake
Brain deuterium metabolic imaging demined glucose uptake measured by glucose to DHO + glucose ratio
Time frame: 2 hours from enrollment to end of assessment
glucose to glx ratio
Brain deuterium metabolic imaging demined glucose to glx ratio
Time frame: 2 hours from enrollment to end of assessment
Clinical information on multiple sclerosis - Disease modifying treatment
Information on current disease modifying treatment are exacted from the hospital patient record
Time frame: 7 days from enrollment to end of assessment
Clinical information on multiple sclerosis - Time since diagnosis
Information on time since diagnosis are exacted from the hospital patient record
Time frame: 7 days from enrollment to end of assessment
Modified Fatigue Impact Scale
A 29-item questionnaire measuring the impact of multiple sclerosis on the patient. With a minimum score of 29 and a maximum of 116, a higher score indicates a worse outcome.
Time frame: 7 days from enrollment to end of assessment
Clinical information on multiple sclerosis - Expanded disability status score
Information on expanded disability status score is exacted from the hospital patient record. The expanded disability status score is a physician rating of disease severity from 0-10 with a higher score indicating higher disability.
Time frame: 7 days from enrollment to end of assessment
Multiple Sclerosis Impact Scale
A 21-item questionnaire measuring the impact of multiple sclerosis on the patient. With a minimum score of 0 and a maximum of 84, a higher score indicates a worse outcome.
Time frame: 7 days from enrollment to end of assessment