Development of Tumor Organoids From Undifferentiated Primary Carcinomas to Guide Therapeutic Decisions

Centre Francois Baclesse20 enrolled

Overview

The study is based on the constitution of a collection of tumor and blood samples for the development of tumoroid for functional tests to predict clinical response to treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Undifferentiated Carcinoma

Interventions

organoid etablishmentOTHER

Prior to initiation of 1st-line therapy: * Collection of an additional study-specific tumor sample for tumoroid analysis (1 fresh tumor sample) * A blood test blood a for tumoroid realization and : * Analysis of ex vivo tumoroid response to treatment and correlation with patient response in vivo * Analysis of correlation between in vivo and ex vivo tumor characteristics * Analysis of first- and second-line survival rates and overall survival

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient with undifferentiated primary carcinoma (UPC) with histological and immunohistochemical evidence, validated in a local and/or national UPC multidisciplinary consultation * Patient with indication for systemic 1st-line treatment at the time of inclusion. Treatment may already have begun at the time of inclusion, but within the limit of 2 treatment cycles administered. * Patient with life expectancy greater than 3 months * Patient of legal age * Patient affiliated to a social security scheme * Signature of informed consent prior to any specific study procedure Exclusion Criteria: * Persons deprived of their liberty or under guardianship (including curatorship) * Pregnant or breast-feeding patient

Locations (1)

Centre François Baclesse

Caen, France

RECRUITING

Outcomes

Primary Outcomes

Rate of establishment of exploitable tumor organoids

Rate of establishment usable tumor organoids for predictive tests of response to treatment.

Time frame: through study completion, an average of 3 years

Central Contacts

zoé NEVIERE, Medical Doctor

CONTACT

33231455050 z.neviere@baclesse.unicancer.fr

Data from ClinicalTrials.gov

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