Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men

Technical University of Munich90 enrolled

Overview

The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is: • Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect. Participants will: * Take 4g of taurine or a placebo every day for 6 months * Visit the study site 4 times for checkups and tests: for a screening visit, at the beginning of the intervention, after 8 and 24 weeks

Measurements performed during study visits: * Biological age estimate via proteome analysis * Organ age estimates (proteomics) * DNA methylation * Inflammatory biomarkers (CRP, cytokines) * Metabolic variables: fasting blood glucose, insulin, HOMA-IR, HbA1c, lipids, BMI * Physical fitness (hand grip strength, leg extensor strength, PWC130) * Resting energy expenditure * Cognitive function via questionnaire * Quality of life * Heart rate variability * Physical activity, nutrition

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Taurine Aging, Biological

Interventions

4g of taurine dailyDIETARY_SUPPLEMENT

Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months

PlaceboDIETARY_SUPPLEMENT

Controll group (4g of placebo/day): 2g of placebo (4 capsules, 500mg each) in the morning and 2g of placebo (4 capsules, 500mg each) in the evening for 6 months

Eligibility

Sex: ALLMin age: 55 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women or men * Age 55 - 75 * BMI 22 - 30 kg/m² * written consent Exclusion Criteria: * Acute or chronic inflammation (e.g. flu infection) * Severe chronic illness (e.g., Type 1 or Type 2 diabetes mellitus, COPD, renal insufficiency) * Myocardial infarction or stroke in the previous 6 months * Psychiatric disorder, including depression or dementia * Weight change of ≥ 5 kg in the last 6 months

Outcomes

Primary Outcomes

Change From Baseline in Biological Age At 6 Months (Proteome Analysis)

The primary objective of the study is to answer the following research question: Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans? Biological age will be determined using a plasma proteome analysis and established machine learning models based on plasma and urine samples. This will also include an analysis of organ-specific aging.

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline in Biological Age At 6 Months (DNA Methylation)

The primary objective of the study is to answer the following research question: Does a 6-month supplementation with 4g of taurine daily slow down biological aging in humans? Biological age will be estimated by assessing DNA methylation patterns (epigenetic clock) from plasma, urine, and oral mucosa samples.

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Secondary Outcomes

Change From Baseline In Cognitive Functions at 6 Months

Does a 6-month supplementation with 4 g of taurine daily influence parameters of mental health? Methods of measurement: MoCA (Montreal Cognitive Assessment)

Time frame: pre-intervention (at time point 0) and post-intervention (after 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: fasting blood glucose in mg/dL

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: Body-Mass-Index determined by participants weight in kilograms divided by height in metres squared.

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: blood pressure in mmHg

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: total cholesterol in mg/dl

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: LDL-cholesterol in mg/dL

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: HDL-cholesterol in mg/dL

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: C-reactive protein in mg/l

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Cardiometabolic Risk Profile at 6 Months

Does a 6-month supplementation with 4 g of taurine daily alter the cardiometabolic risk profile? Measurement: fasting insulin in pmol/l

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Handgrip Strength (kg) at 6 Months

Measurement of handgrip strength in kilograms and Newtons in the dominant hand using Jamar Hydraulic Hand Dynamometer.

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Physical Working Capacity (PWC130) At 6 Months

Measurement of heart rate (bpm) on the Corvial ergometer while increasing power manually by 25 W every 2 minutes. The endpoint is the power in Watts at the stage where heart rate of 130bpm is reached.

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Change From Baseline In Isometric Leg Extensor Strength For Each Leg At 6 Months

Measurement of leg extensor strength using a force transducer connected to the back of a chair and an ankle loop, as well as force recording software. The maximum force (N) will be multiplied with the distance from knee joint to the middle of the loop (in metres) to calculate the torque in Newton-metres (Nm) for each leg.

Time frame: pre-intervention (at time point 0) and post-intervention (at 24 weeks)

Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes