Frailty, Hip Fractures and Inflammatory Biomarkers

University of Thessaly200 enrolled

Overview

We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.

Frailty (F) is a prevalent syndrome among elderly patient with hip fractures (HF) and has been linked to poor prognosis. Inflammatory biomarkers have been used as prognostic indexes in patients with HF. We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Frailty Hip Fracture Inflammatory Biomarkers

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \&gt;65 years, ASA PS I-III, non- institutionalized, able to communicate patients Exclusion Criteria: * Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate

Locations (2)

Larissa University Hospital

Larissa, Thessaly, Greece

RECRUITING

UHL

Larissa, Thessaly, Greece

RECRUITING

Outcomes

Primary Outcomes

Frailty status

Frailty will be categorized based on the validated Groningen Frailty Indicator (GFI) as non-frail (NF, score 0,1), pre-frail (PF, score 2, 3) and severe frail (SF, score \>4).

Time frame: preoperatively

Inflammatory biomarkers

Upon admission and immediate before surgery upper limits of white blood cells (WBC) within normal range (WBC \>8 10\^3/μL), NLR (neutrophils/lymphocytes), PLR (platelets/lymphocytes), CRP (C-reactive protein) and CLR (CRP/lymphocytes), will be recorded.

Time frame: preoperatively

Central Contacts

Eleni Arnaoutoglou, Professor

CONTACT

+302413502952 earnaout@gmail.com

Maria Ntalouka, MD, PhD, MSc

CONTACT

Data from ClinicalTrials.gov

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