Dexmedetomidine Dosage for Postoperative Delirium and Cognitive Function in Elderly TKA Patients

Tanta University132 enrolled

Overview

This study aims to evaluate the efficacy of dexmedetomidine in reducing the incidence of postoperative delirium and cognitive dysfunction in elderly patients undergoing total knee arthroplasty (TKA). The study will compare the outcomes of patients receiving dexmedetomidine to those receiving a standard anesthetic or sedative, focusing on factors such as patient characteristics, surgical duration, and postoperative care. The research will explore the potential neuroprotective effects of dexmedetomidine and its ability to mitigate the risks associated with anesthesia and surgery in vulnerable elderly populations.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

132

Conditions

Post Operative Delirium

Interventions

Dexmedetomidine (Precedex, 100 µg/ml) was provided as an intravenous (IV) loading dose of 1 µg/kg over 10-min

Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML)DRUG

Dexmedetomidine infusions were prepared to provide 0.5 µg/kg/h

Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML)DRUG

Dexmedetomidine infusions were prepared to provide 0.7 µg/kg/h

Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML)DRUG

Dexmedetomidine infusions were prepared to provide 1.1 µg/kg/h

Normal salineDRUG

loading dose of saline was injected 10-min before induction of anesthesia.

Eligibility

Sex: ALLMin age: 35 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with Severe chronic knee osteoarthritis inducing limitation of movement and required knee replacements; * Patients of American Society of Anesthesiologists Classification grades II-III; * Patients free of exclusion criteria. Exclusion Criteria: * Patients of American Society of Anesthesiologists Classification grade \>III; * Patients show a high risk for getting Post Operative Delirium or have severe cognitive dysfunction; * Patients had a history of uncompensated cardiac, renal, or hepatic diseases; * Patients had uncontrolled diabetes mellitus or hypertension; * Patients had other causes for limited movement; * Patients had autoimmune disease, coagulopathy, severe anemia with a hemoglobin concentration of \<7 g%; * Patients had local bone disorders that may prevent prosthesis stability; * Patients had allergies or contraindications to the study drugs.

Locations (1)

Tanta University

Tanta, El Gharbyia, Egypt

Outcomes

Primary Outcomes

Proportion of patients reporting at least a 50% reduction of Postoperative Delirium (measured by Confusion Assessment Method, Delirium Index) post-Total knee arthroplasty under sevoflurane inhalational anesthesia.

Time frame: 3 months

Data from ClinicalTrials.gov

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