To explore the impact of esketamine combined with ciprofol on the quality of early postoperative recovery in elderly patients undergoing painless gastroscopy, as well as the effectiveness and safety of this regimen.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
376
R group will be started with remifentanil 0.5ug/kg and ciprofol 0.4 mg/kg.
Anesthesia induction was initiated by esketamine 0.3mg/kg, followed by ciprofol 0.2-0.4mg/kg.
Anesthesia induction was initiated by esketamine 0.5mg/kg, followed by ciprofol 0.2-0.4mg/kg.
Subei People's Hospital of Jiangsu Province
Yangzhou, Jiangsu, China
postoperative day 1(POD1) Quality of Recovery(QoR)-15 questionnaire score
Quality of life will be evaluated using Quality of Recovery(QoR)-15 questionnaire score at postoperative day 1(minimum value : 0, maximum value : 150, the higher the score, the better the result)
Time frame: Baseline (30 min before surgery), postoperative day 1
postoperative day 3(POD3) Quality of Recovery(QoR)-15 questionnaire score
Quality of life will be evaluated using Quality of Recovery(QoR)-15 questionnaire score at postoperative day 3(minimum value : 0, maximum value : 150, the higher the score, the better the result)
Time frame: Postoperative day 3 and 7
Cognitive function assessment
A Mini-Mental State Examination (MMSE) is a set of 11 questions that doctors and other healthcare professionals commonly use to check for cognitive impairment (problems with thinking, communication, understanding and memory). MMSE has a maximum total score of 30, with higher scores manifesting a better cognitive performance.
Time frame: Baseline (30 min before surgery), postoperative day 1,3 and 7
Hospital anxiety and depression scale ( HADS ) score.
Postoperative anxiety and depression scores will be measured by the Hospital Anxiety and Depression Scale, on the morning(8-10 am) of postoperative days (PODs) 1,3 and 7 , a score of 8 points or higher will be diagnosed as depression or anxiety.
Time frame: Baseline (30 min before surgery), postoperative day 1,3 and 7
Dosage of ciprofol
Consumption of ciprofol during endoscopic examination
Time frame: During endoscopic examination
Heart rate (HR)
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Ciprofol group will be started with ciprofol 0.2-0.4 mg/kg.
Throughout the procedure, the heart rate (HR) was continuously monitored.
Time frame: Baseline,during surgery and arrived at PACU (up to 30 minutes after surgery)
Pulse oxygen saturation (SpO2)
Throughout the procedure, the pulse oxygen saturation (SpO2) were continuously monitored.
Time frame: Baseline, during surgery and arrived at PACU (up to 30 minutes after surgery)
Mean blood pressure (MBP)
Throughout the procedure, the mean blood pressure (MBP) was measured at 1-minute intervals.
Time frame: Baseline, during surgery and arrived at PACU (up to 30 minutes after surgery)
Patient satisfaction levels
The patients express their satisfaction with procedures on a visual analogue score, ranging from 0 to 10, where 0 is the minimum and 10 is the maximum satisfaction level.
Time frame: 30 minutes at recovery room.