Sickle cell disease is characterized by chronic hemolytic anemia and blood rheological alterations. In addition, blood coagulation abnormalities have been reported in patients with sickle cell disease and hemolysis-derived products could be involved. The investigators hypothesized that patients with sickle cell disease and severe hemolysis (Lactate Dehydrogenase level \> 484 IU/L) could have an increased risk of hypercoagulable state and subsequent thromboembolic complications.
Study Type
OBSERVATIONAL
Enrollment
200
3 additional citrate tubes (2.7mL)
Insitut Hématologique et Oncologique Pédiatrique (IHOPe)
Lyon, France
Service de Médecine Interne - Hôpital Edouard Herriot
Lyon, France
Overall coagulation activity
To compare the overall coagulation activity (measurement of in vitro clot formation by rotary thromboelastometry (ROTEM)) between sickle cell patients with a severe haemolytic phenotype and those with a less severe haemolytic phenotype.
Time frame: Baseline
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