The purpose of this study is to evaluate the anti-wrinkle efficacy and effect on skin epigenetic and on mitochondrial morphology of a facial cosmetic product compared to a placebo
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
36
cosmetic cream to be applied topically on face and forearms twice/daily using split/face design
cosmetic cream to be applied topically on face and forearms twice/daily using split/face design
SGS proderm GmbH
Schenefeld, Hamburg, Germany
Anti-wrinkle efficacy
Anti-wrinkle efficacy will be assessed in the periorbital regions wrinkles using AEVA. Parameters measured: Rz and Ra, representing mainly the rough structure (Rz) or the finer skin structure (Ra).
Time frame: 12 weeks
Skin Biological age
DNA methylation patterns analysis (epigenetics) by skin tape stripping (D-Squames)
Time frame: 12-weeks
Skin hydration
Change from baseline in skin hydration (assessed on skin capacitance by Corneometer \[a.u.\])
Time frame: 12 weeks
Transepidermal Water Loss (TEWL)
Change from baseline in skin barrier function (assessed as transepidermal waterloss by Tewameter \[g/(m²h)\])
Time frame: 12 weeks
Mitochondrial morphology in skin
mitochondrial morphology in skin will be assessed via transmission electron microscopy (TEM) on 3mm punch-biopsies
Time frame: 12 weeks
Photodocumentation of skin health
ColorFace image analysis of face via facial photography
Time frame: 12 weeks
Subjective questionnaire
Subjective evaluation of product traits assessed via questionnaire
Time frame: 12 weeks
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