The goal of this study is to compare the intraoperative hemodynamic status, characteristics of block of fractionated versus single bolus dose of Hyperbaric Bupivacaine in patient undergoing Transurethral Resection of Prostate(TURP) surgery under Subarachnoid block(SAB). Seventy-two patients aged 50 years and above belonging to American Physical status I and II are divided into two study group. Group B will receive Injection 0.5 % hyperbaric bupivacaine 2.5 ml single bolus dose and group F will receive same concentration and volume of hyperbaric bupivacaine with two third dose initially (i.e. 1.6 ml) and remaining one third dose (i.e. 0.9 ml) after 60 seconds at the rate of 0.2ml/sec.
The aim of this study is to compare the intraoperative hemodynamic status, characteristics of block of fractionated versus single bolus dose of Hyperbaric Bupivacaine in patient undergoing TURP surgery under SAB. Seventy-two patients aged 50 years and above belonging to American Physical status I and II undergoing transurethral resection of prostate for benign enlargement of prostate under subarachnoid block are enrolled and are divided into two groups having 36 patients in each. Group B will receive Injection 0.5 % hyperbaric bupivacaine 2.5 ml single bolus dose and group F will receive same concentration and volume of hyperbaric bupivacaine with two third dose initially (i.e. 1.6 ml) and remaining one third dose (i.e. 0.9 ml) after 60 seconds at the rate of 0.2ml/sec. Intraoperative mean arterial pressure (MAP), heart rate, onset of sensory and motor block, duration of sensory and motor block, and total intraoperative consumption of vasopressor are observed and compared between the groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
72
There are two groups.
National Academy of Medical Sciences, Bir Hospital
Kathmandu, Nepal
Comparision of mean arterial pressure(MAP) in both participants with subarachnoid block
Hypotension was defined when mean arterial pressure (MAP) decreased ≤20% from baseline.
Time frame: Throughout study completion,an average of 3 months
Comparision of heart rate in both participants with subarachnoid block
Bradycardia was defined when heart rate is less than 60 beats per minute.
Time frame: Throughout study completion,an average of 3 months
Comparision of total consumption of vasopressors used during intraoperative period between the groups.
Injection Mephentermine 6mg iv was given for hypotension
Time frame: Throughout study completion,an average of 3 months
Comparision of time for onset of sensory between the groups.
Sensory block was assessed by loss of sensation to pinprick with blunted tip needle bilaterally in the dermatomal levels. It was tested every 3 min until achievement of maximum sensory block i.e. till T10 level
Time frame: Throughout study completion,an average of 3 months.
Comparision of time for onset of motor block between the groups
Time required to reach Modified Bromage scale =3, where Bromage 0= no motor block ,Bromage 3= complete block of motor limb
Time frame: Throughout study completion,an average of 3 months.
Comparision of the time of regression of sensory block between two groups.
Loss of pinprick sensation every 30 minutes postoperatively until it reached the S2 segment
Time frame: Throughout study completion,an average of 3 months
Comparision of the time of regression motor block between two groups.
Assessed every 30 minutes postoperatively Time required to reach Modified Bromage scale =0, where Bromage 0= no motor block ,Bromage 3= complete block of motor limb.
Time frame: Throughout study completion,an average of 3 months.
Comparision of adverse effects like nausea, vomiting and shivering between the groups
Side effects managed according to hospital protocol
Time frame: Throughout study completion,an average of 3 months.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.