The effect of iodine nutritional status on thyroid cancer has been controversial for many years. We designed a prospective cohort study that recruiting patients in different iodine areas who underwent thyroid cancer surgery in branch hospitals from 2012 to 2019，and follow up their clinical outcomes. We aimed to analyse the relationship between regional iodine nutrition level and pathological types, clinical features, and prognosis of thyroid cancer.
Three sub centers were selected in high iodine (Jining/Liaocheng/Heze) and moderate iodine (Jinan/Shenyang/Haerbin) areas respectively. Patients lived in the above-mentioned regions for at least 5 years and diagnosed as thyroid cancer and underwent thyroid surgery in branch hospitals from 2012 to 2019 were recruited.
Study Type
OBSERVATIONAL
Enrollment
1,600
Iodine excess areas: water iodine ≥100μg/L; or urinary iodine concentration (median urinary iodine levels in children aged 8-10 years old)≥300μg/L
Iodine suitable areas：water iodine ≥40μg/L and ≤100μg/L; or urinary iodine concentration(median urinary iodine levels in children aged 8-10 years old) 100-199μg/L.
Shandong Provincial Hospital
Jinan, Shandong, China
RECRUITINGNumber of participants with recurrence
Recurrence: diagnosed as the same type of thyroid cancer again by pathology
Time frame: from enrollment to the final follow-up at 5 years
Number of participants with distant metastasis
Distant metastasis: Pathological confirmed thyroid cancer occurring outside the thyroid gland
Time frame: from enrollment to the final follow-up at 5 years
All-cause mortality
The ratio of the total number of deaths caused by various reasons during the research period to the number of participants
Time frame: from enrollment to the final follow-up at 5 years
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