Prostasin Levels in Preeclamptic Women

Başakşehir Çam & Sakura City Hospital88 enrolled

Overview

This study will aim to compare maternal serum prostasin levels between women diagnosed with preeclampsia and healthy normotensive pregnant controls. Participants will be divided into two main groups: those with preeclampsia and those with uncomplicated pregnancies. The preeclampsia group will further be subdivided based on the severity of the condition. Maternal serum samples will be collected from all participants, and prostasin levels will be measured using ELISA. Statistical analyses will be performed to evaluate whether prostasin levels are significantly elevated in the preeclampsia group, particularly in those with severe features, and to assess its potential as a biomarker for the condition.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pre-Eclampsia

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of Preeclampsia: Defined by new-onset hypertension (systolic Blood Pressure ≥140 mmHg and/or diastolic Blood Pressure ≥90 mmHg) after 20 weeks of gestation, with or without proteinuria. * Control Group: Healthy pregnancies without preeclampsia or other significant maternal or fetal complications. Exclusion Criteria: * Multiple Pregnancies * Pregestational Diabetes * Chronic Hypertension * Systemic Diseases (Chronic kidney disease, autoimmune diseases) * Fetal Anomalies * Premature Rupture of Membranes.

Locations (1)

Outcomes

Primary Outcomes

Maternal Serum Prostasin Levels

To compare Prostasin Levels between the pre-eclampsia and the control group.

Time frame: Up to 8 weeks (Patients will be followed from inclusion in the study until the end of their pregnancy.