Ventilator Mode and Respiratory Physiology

N/AEnrolling By InvitationNCT06624254

University of California, San Diego60 enrolled

Overview

Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Disease Respiratory Failure Respiratory Effort Breathing Mechanics

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Admitted to ICU with acute respiratory failure * On adaptive pressure control mode of ventilation * Tidal volumes set between 5-8 cc/kg ideal body weight Exclusion Criteria: * Current use of neuromuscular blockade * Inability to obtain consent from patient or surrogate decision maker * Treating clinician refusal

Outcomes

Primary Outcomes

Excess tidal volume

Exhaled tidal volume greater than 2cc/kg ideal body weight above intended or set tidal volume

Time frame: From enrollment to end of monitoring at 4 hours