The study investigates the effectiveness of the natural product Dandelion in treating obesity in premenopausal women through a randomized interventional trial, measuring various parameters and biomarkers.
The study aims to explore the anti-obesity effects of dandelion supplementation in premenopausal obese women. The research will measure changes in appetite, energy intake, body weight, composition, lipid profile, and inflammatory markers, providing evidence of dandelion\'s efficacy as an anti-obesity phototherapy. The randomized interventional trial will measure multiple parameters and biomarkers.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
120
The Xenical group will receive identical capsules 120mg (one capsule) to be taken three times daily with meals, equaling 360mg total daily dose, which aligns with the usage in adult female patients
The dandelion extract group will receive 500 mg capsules of dandelion leaf extract, given 3 times per day before meals.
October 6 University Hospital
Giza, Egypt
Changes in body weight
Time frame: monthly change, assessed up to 3 months
Change in fat mass
Time frame: Monthly change, assessed up to 3 months
Appetite Ratings
Time frame: monthly change, assessed up to 3 months
Dietary intake via 24-hour recalls
Time frame: Recorded for patients daily, assessed up to 3 months
Lipid profile
Time frame: Monthly change, assessed up to 3 months
CRP
C-reactive protein
Time frame: Monthly change, assessed up to 3 months
TNF-α
Time frame: Monthly change, assessed up to 3 months
IL-6
Interelukine 6
Time frame: Monthly change, assessed up to 3 months
IL-16
Time frame: Monthly change, assessed up to 3 months
Glycemic indices
Time frame: Monthly change, assessed up to 3 months
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