The study is a retrospective observational study. The study is designed to be multicentric and international and it will analyze medical records from selected patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy. There are no risks for the patients, as this is a retrospective data collection.
The use of neoadjuvant chemo-immunotherapy for the treatment of non-small cell lung cancer (NSCLC) is increasing. However, there is limited research comparing the feasibility and oncologic efficacy of robot-assisted thoracoscopic surgery (RATS), video-assisted thoracoscopic surgery (VATS), and open lung resection, in patients already treated with neoadjuvant chemo-immunotherapy. This study aims to evaluate the benefits of RATS compared to VATS and open surgery in terms of short-term outcomes for patients with NSCLC undergoing neoadjuvant chemo-immunotherapy. All adult patients diagnosed with locally advanced and resectable NSCLC who underwent lung resection from 01-01-2016 to 31-03-2024 by robotic, VATS and open approach after receiving neoadjuvant chemo-immunotherapy will be included. Patients are divided into three groups: robotic lung resection; video-assisted thoracoscopic (VATS) lung resection; open lung resection.
Study Type
OBSERVATIONAL
Enrollment
140
Baptist Health South Florida
Miami, Florida, United States
RECRUITINGMemorial Sloan Kettering Cancer Center
New York, New York, United States
RECRUITINGWest Virginia University
Morgantown, West Virginia, United States
RECRUITINGIstituto Clinico Humanitas
Rozzano, Milan, Italy
RECRUITINGScientific Institute Ospedale San Raffaele
Milan, Italy
RECRUITINGRegina Elena National Cancer Institute
Rome, Italy
RECRUITINGThe perioperative complication of video-assisted thoracoscopic surgery (VATS) approach
The investigators will measure the perioperative complications of VATS approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
Time frame: 30-90 days after surgery
The perioperative complications of robotic approach
The investigators will measure the perioperative complications of robotic lung resection in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
Time frame: from the surgery at 30-90 days after
The perioperative complications of the open approach
The investigators will measure the perioperative complications of open approach in patients who received neoadjuvant chemo-immunotherapy. Complications will be categorized according to the Clavien-Dindo scale.
Time frame: 30-90 days after surgery
Duration of surgery
Duration of the surgery based on the approach measured in minutes
Time frame: from 30 days after surgery
Quality of lymphadenectomy
Number of lymphonodes station resected
Time frame: from 30 days after surgery
Conversion rate
Number of surgery procedures converted
Time frame: from 30 days after surgery
Radicality of the resection
Radicality of the resection in the approaches
Time frame: from 30 days after surgery
Oncological treatment
Response of the patient to oncological treatment
Time frame: from 30 days after surgery
Survival analysis
Presence or absence of local and distant relapse
Time frame: from 3 to 5 years after surgery
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