Asprosin Level in Individuals With Periodontal Disease

Mustafa Kemal University75 enrolled

Overview

The aim of this study was to investigate the levels of asprosin hormone and tumour necrosis factor alpha (TNF-α) in gingival crevicular fluids and to compare its level with those in saliva and serum in patients with gingivitis and periodontitis.

This study is investigating the level of asprosin hormone in gingival crevicular fluid of patients with periodontal diseases such as gingivitis and periodontitis, and observing the healthy patient in terms of the hormone levels, as well. 75 volunteer patients aged 18-45 years old were included in this study. These patients were divided equally to three groups: Group I; periodontal health, Group II; gingivitis, Group III; periodontitis.The body fluids including serum, saliva and gingival crevicular fluid were collected from this participants according to the proper protocol and their storage was provided under certain conditions. ELISA tests for asprosin and Tumour necrosis factor alpha were made in laboratory. Also, clinical measurements such as plaque index, bleeding on probing, probing pocket depth were recorded at first visit day of the participants. The data were analysed according to the different periodontal conditions, and correlated with asprosin hormone and tumour necrosis factor alpha level in gingival crevicular fluid, serum and saliva.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Periodontitis Periodontal Health Gingivitis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Exclusion Criteria: * Those with any systemic disease * Individuals who take medication regularly * Pregnant or lactating women * Individuals with menopause and anthropause * Those who have undergone any periodontal treatment in the last six months * Smokers

Locations (1)

Adiyaman University, Faculty of Dentistry

Adıyaman, Turkey (Türkiye)

Outcomes

Primary Outcomes

Asprosin level

Asprosin level (ng/mL) in gingival crevicular fluid, serum and saliva.

Time frame: Day 1

Secondary Outcomes

TNF-alpha levels

TNF-alpha level (pg/mL) in gingival crevicular fluid, serum and saliva

Time frame: Day 1

Plaque index

The index was recorded from all participants as numerical between 0-3

Time frame: Day 1

bleeding on probing

The bleeding on probing is stated by percentage. the ratio of the number of sites with bleeding gingiva on probing around teeth to total surfaces of all examined teeth

Time frame: Day 1

probing pocket depth

The parameters were recorded as mm in all participant. The probing pocket depth is measured from the marginal gingiva to bottom of pocket using a periodontal probe, from six surfaces of each tooth.

Time frame: Day 1

body mass index

the weight and height is combined to report BMI in kg/m2

Time frame: Day 1

Data from ClinicalTrials.gov

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