SN514-066b Enzyme in Deep Partial Thickness Burns

Main Inclusion Criteria: 1. Thermal burns caused by fire/flame, scalds or contact 2. Total burns area available for treatment is 25 to 500 cm2 (a larger area may be burned, but the treatment area must be limited to the stated size, and the treatment area must be exclusive of face, hands, genitalia and sites deemed to be at high risk for developing compartment syndrome) 3. Target burns for treatment is deep partial thickness (DPT) in depth Main Exclusion Criteria: 1. Subject has another life threatening traumatic injury 2. Patient's proposed study wound site has any of the following conditions: * Electrical or chemical etiology * Pre-enrollment escharotomy * Area is devoid of circulation * Located on the face, perineum or genitalia * Clinical evidence of wound infection 3. Poorly controlled diabetes mellitus (HbA1c \>12%) 4. BMI greater than 40 kg/m2 5. Cardio-pulmonary disease (MI within 6 months prior to injury, severe or unstable ischemic heart disease, severe or unstable heart failure, severe pulmonary hypertension, severe COPD or pre-existing oxygen-dependent pulmonary diseases, severe broncho-pneumonia within 1 month prior to injury, steroid dependent asthma, or uncontrolled asthma) 6. Pre-existing diseases which interfere with circulation (severe peripheral vascular disease, severe circulatory edema and/or lymphedema, regional lymph nodes dissection, significant varicose veins) 7. Any conditions that would preclude safe treatment or adding further risk to the basic acute burn trauma (such as severe immuno-compromising diseases, life threatening trauma, severe pre-existing coagulation disorder, severe cardiovascular disorder, significant pulmonary disorder, significant liver disorder including post alcoholic abuse impaired function or neoplastic disease, blast injury)