This is the prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable Gastroesophageal Cancer (GEC) and non-small-cell lung cancer (NSCLC).
This is the prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable Gastroesophageal Cancer (GEC) and Non-Small-Cell Lung Cancer (NSCLC). Eligible patients were administered first-line treatment with either immune checkpoint inhibitor or a combination of immunotherapy and chemotherapy upon enrollment. This study will have 2 cohorts: * Cohort 1: A prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable GEC patients. * Cohort 2: A prospective, observational cohort study to explore the impact of pretreatment emotional distress on survival and the predictive role of peripheral blood metabolic and inflammatory markers in immunotherapy response among treatment-naïve, advanced and inoperable NSCLC patients.
Study Type
OBSERVATIONAL
Enrollment
196
The assessment of depressive and anxiety symptoms was conducted using Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder Assessment 7 (GAD-7). Patients with a sum score of PHQ-9 and GAD-7 ≥ 10 were categorized as the stressed group.
Second Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
Cohort 1 & 2: Progression-free survival (PFS)
Time from the beginning of first-line immunotherapy to the first progression (PD) or death in patients
Time frame: 4 year
Value of Neutrophils to lymphocytes ratio (NLR)
NLR is an inflammatory marker, which is the ratio of neutrophils to lymphocytes. The higher the value is, the higher the inflammatory level may be. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Platelet-lymphocyte ratio (PLR)
PLR is an inflammatory marker, a ratio of platelets to lymphocytes. A higher value of it indicates a higher level of inflammation in the body. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Monocyte-lymphocyte ratio (MLR)
MLR is an inflammatory indicator, which is the ratio of macrophages and lymphocytes. The higher the value is, the higher the inflammatory level in the body is. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Systemic immune inflammation index (SII)
SII is an inflammatory indicator, which is calculated as follows: SII= (neutrophil × platelet)/lymphocytes. A higher value indicates an elevated level of inflammation within the body. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Pan-immune inflammation value (PIV)
PIV is an inflammatory indicator, which is equal to neutrophils × monocytes × platelets/lymphocytes. The higher the value is, the higher the inflammatory level in the body is. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of eosinophil fraction
The eosinophil fraction is a potential inflammation and tumor prognostic indicator, which equals the ratio of eosinophil absolute value to the total white blood cell count. The higher the value of this fraction, the better the tumor prognosis may be. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of prognostic nutritional index (PNI)
PNI is a potential inflammation and tumor prognostic indicator, which is equal to albumin level (g/L) + 5 × absolute value of lymphocyte counts. The higher the value of this index, the better the tumor prognosis may be. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Blood glucose
Blood glucose is an indicator of metabolism in the body. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Triglycerides
Triglycerides is an indicator of metabolism in the body. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Total cholesterol
Total cholesterol is an indicator of metabolism in the body. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Value of Albumin
Albumin is an indicator of metabolism in the body. The information has been extracted from the medical record and evaluated longitudinally.
Time frame: 0 day, 6 weeks
Disease Control Rate (DCR)
DCR refers to the proportion of patients with tumor treated with a certain treatment who have tumor shrinkage or stable disease, and this state can be maintained for a certain period of time, including the proportion of Complete Response (CR), Partial Response (PR) and Stable Disease (SD).
Time frame: 1 year
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