Spinal cord stimulation (SCS) has proven to be effective for pain that is unresponsive to medication. This technique involves an anesthesiologist or a neurosurgeon placing stimulation electrodes at the thoracic vertebrae to provide pain relief. Although SCS is not currently a standard treatment for patients with Parkinson's disease, recent studies have shown that Parkinson's patients who experience intolerable pain and undergo SCS treatment not only experience pain relief but also show improvements in gait and other Parkinson's symptoms. Therefore, the investigators aim to use temporary, minimally invasive SCS electrodes to help patients with nrFOG (non-responsive Freezing of Gait) improve their stability and reduce their risk of falls.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
5
300Hz/300us
130Hz/300us
60Hz/300us
National Taiwan University Hospital Hsin-Chu Branch
Hsinchu, Hsinchu City, Taiwan
RECRUITINGGait parameters --- foot rotation [degtree]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- step length [cm]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- stride length [cm]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- step width [cm]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- stance phase [%]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- swing phase [%]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- double stance phase [%]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- step time [second]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- stride time [second]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- cadence [steps/minute]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Gait parameters --- velocity [km/hour]
(1)Measured by plantar pressure distribution measurement systems (100 Hz, FDM-T, Zebris Medical GmbH, Germany) with a maximum gait track of 6 meters.
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Clinical Scale
1. Tinetti Gait Analysis 2. Score: 0-16 (Higher scores means better.)
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Clinical score
1. MDS-UPDRS part III (motor examination) 2. Score: 0-72 (Higher scores means worse.)
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Clinical Scale
1. Time up and Go test 2. Patients wear their regular footwear and can use a walking aid, if needed. Begin by having the patient sit back in a standard arm chair and identify a line 3 meters, or 10 feet away, on the floor. 3. Score: Time in Seconds (Shorter time means better.)
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Clinical Scale
1. Freezing of gait questionnaire 2. Score: 0-26 (Higher scores means worse.)
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
Clinical Scale
1. Activities-specific balance confidence scale 2. Score:0%-100% (Higher percentage means better.)
Time frame: Day 0, Day 2, Day 3, Day 4, and Day 7
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