Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion

Sir Run Run Shaw Hospital200 enrolled

Overview

This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy evaluation and prognostic prediction of the LVO patients with low NIHSS.

It was reported that about two third of the stoke patients might present with minor or mild stroke symptoms. 20-40% of those minor stroke patients had large vessel occlusion (LVO). AIS patients with LVO and low NIHSS are common and has been associated with early neurological deterioration and worse outcomes. Until now, the best therapy strategy for the acute stoke patients with minor stroke and large vessel occlusion is unknown. Thus, we sought to (1) explore the potential predictors of acute neurological deterioration and 90-day clinical outcome; (2) and evaluate the best therapy strategy.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Stroke, Acute Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Vascular Diseases Brain Infarction

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Aged 18 years or older 2. Acute ischemic stroke patients of NIHSS 0-5 with 24 hours after onset 3. Proximal intracranial artery occlusion on NCCT/CTA or MRI/MRA showing occlusion of the intracranial ICA, M1, or proximal M2 vessel 4. Baseline ASPECTS ≥6 or infarct Core Volume of \< 70 on NCCT/DWI/CTP 5. Pre-mRS≤1 Exclusion Criteria: 1. Any sign of intracranial hemorrhage on baseline CT/MR; 2. Seizures at stroke onset 3. Baseline blood glucose of \<2.78 mmol or \>22.20 mmol, or platelet count \< 100,000/uL or serum creatinine levels \> 3.0 mg/dL 4. Participation in any investigational study in the previous 30 days

Outcomes

Primary Outcomes

modified Rankin Scale at 90 days

Time frame: 90 days

acute neurological deterioration

It is neurological deterioration of presumed ischemic origin with an NIHSS score increase of 4 points or more within the 24 hours after onset.

Time frame: 24 hours

Secondary Outcomes

Incidence of symptomatic intracerebral hemorrhage

Incidence of symptomatic intracerebral hemorrhage according to ECASS II criteria

Time frame: 2-3 days

patients with good outcome comparing the two treatment groups

Good outcome is defined as a score of 0-2 on the 90-day mRS