Sarcopenia is a frequent complication in patients with cancer and chronic diseases, it is characterized by decreased muscle strength and fatigue due to reduced skeletal muscle mass, which is accompanied by atrophy and decreased quality of muscle tissue. In all cases, it negatively impacts treatment tolerance, clinical outcomes and survival, in consequence, quality of life of these patients decreases while morbidity, mortality and costs increase. In this context, appropriate nutritional screening and early nutrition support are extremely recommended, to this aim, in some cases, oral nutritional supplements (ONS) are necessary; ONS could have a standard formula or be enriched with specific nutrients. There is a lack of evidence for supporting its use or the use of protein modules in other clinical conditions including patients with heart failure
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Mediterranean diet recommendations and daily physical exercise
Hypercaloric, hyperproteic oral supplement combined with Mediterranean diet recommendations (2 per day) and daily physical exercise
Protein module (10g/day) combined with Mediterranean diet recommendations and daily physical exercise
Calcifediol supplement administered orally in order to reach sufficiency levels (30 ng/ml)
Physical exercise adapted to patients with heart failure (Cardiac rehabilitation)
IMIBIC
Córdoba, Cordoba, Spain
Muscle mass
Changes in muscle mass
Time frame: 6 months
Functionality
Changes in functionality determined by the up and go test
Time frame: 6 months
Albumin
Changes in serum albumin levels (g/dl)
Time frame: 6 months
C-RP
Changes in serum C-RP (g/dl)
Time frame: 6 months
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