The current prospective observational pilot study aims to evaluate the endocrine profile of a single-injection protocol (single CFA + daily oral administration of CC).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
On day 2 or 3 of the menstrual cycle or after 5 days of pill-free interval, a single injection of 150 mcg of CFA (Stimulation Day 1) will be administered.
On day 2 or 3 of the menstrual cycle or after 5 days of pill-free interval, the patients will start oral administration of Clomiphene Citrate 100/day continuing up to and including the day of ovulation triggering
Scan controls and blood exams will be performed on stimulation days 1, 6, 8, 10 and, according to clinical needs, until trigger day.
Dexeus Mujer Sabadell
Sabadell, Barcelona, Spain
Dexeus Mujer Sant Cugat
Sant Cugat del Vallès, Barcelona, Spain
Departamento de Ginecología Obstetricia y Reproducción. Hospital Universitari Dexeus
Barcelona, Spain
Estradiol
Estradiol levels
Time frame: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
Progesterone
Progesterone levels
Time frame: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
Follicle stimulating hormone (FSH)
FSH levels
Time frame: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
Luteinizing hormone (LH)
LH levels
Time frame: days 1, 6, 8, 10,the day of ovulation triggering, the day of ovulation triggering day+1 and 7 days after oocyte retrieval
Days of stimulation
Time frame: 7 -20 days from initiation of ovarian stimulation
Number of oocytes retrieved (COCs)
Time frame: 7 -20 days from initiation of ovarian stimulation
Number of MII oocytes
Time frame: 7 -20 days from initiation of ovarian stimulation
Follicular Output Rate (FORT)
expressed as the ratio between the total number of oocytes retrieved at oocyte pick-up and the number of antral follicles available at the start of stimulation
Time frame: 7 -20 days from initiation of ovarian stimulation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Follicle-to-oocyte index (FOI)
expressed as the ratio between the total number of oocytes retrieved at oocyte pick-up and the number of antral follicles available at the start of stimulation
Time frame: 7 -20 days from initiation of ovarian stimulation
Cancellation rate
Time frame: 7 -20 days from initiation of ovarian stimulation
Ovarian hyperstimulation syndrome (OHSS) rate
Time frame: Until 15 days after punction