Efficacy of Nanodropper-mediated Topical Anesthetic

Columbia University56 enrolled

Overview

The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a "Nanodropper" adaptor. The Nanodropper is designed to administer smaller-sized drops, or microdrops. Participants will: 1. Complete a baseline eye exam. 2. Receive a numbing drop using a standard dropper in one eye and the Nanodropper in the other eye. 3. Have their eyes tested for numbness at specific time points (30 seconds, 1, 2, 5, and 10 minutes after getting the drops). 4. Tell the researchers if they feel pain during the eye sensation tests. 5. Complete a survey about their experience with the eyedrops and testing procedure. This study could help us find a way to use less medication while still effectively administering eye medications, potentially saving money and reducing medical waste.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DEVICE_FEASIBILITY

Masking

TRIPLE

Enrollment

Conditions

Corneal Diseases Effectiveness of Microdrops

Interventions

Nanodropper and Proparacaine HCl 0.5%COMBINATION_PRODUCT

The Nanodropper is an eyedrop bottle adaptor that creates smaller eyedrops by coupling to an existing eyedrop bottle. This intervention involves the administration of proparacaine HCl 0.5% using the Nanodropper.

Standard Eye Drop Bottle with Proparacaine HCl 0.5%COMBINATION_PRODUCT

This intervention involves administration of proparacaine HCl 0.5% using a standard eye drop bottle.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Ability to provide informed consent for topical anesthesia delivery 2. Ability to verbally respond to pain 3. At least 18 years of age Exclusion Criteria: 1. Have a contraindication to local anesthetics 2. History of intravitreal injections 3. History of ocular surgery 4. History of vitreous or retinal surgery 5. Preexisting diagnosis of ocular surface disease requiring punctal plug placement 6. Evidence of any current ocular inflammation 7. Any previous ocular condition (i.e., neurotrophic keratitis, herpetic eye disease, presence of a corneal graft, etc.) that has permanently altered the native sensation of the ocular surface 8. Use of contact lenses in the past 2 weeks 9. Use of exclusionary medications: Topical steroid drops, non-steroidal anti-inflammatory drops, intraocular pressure lowering eye drops, any anti-viral medications used for herpes, opioids

Efficacy of Nanodropper-mediated Topical Anesthetic

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes