Correlation Analysis of Xpert Carba-R Detection of Non-colonized CRE in BALF and Rectal Swabs From Patients With LRTI

N/AEnrolling By InvitationNCT06636890

The First Affiliated Hospital with Nanjing Medical University200 enrolled

Overview

Assess the correlation between Xpert Carba-R detection of carbapenemase gene types in bronchoalveolar lavage samples and rectal swab samples from non-colonized CRKP patients with lower respiratory tract infections, and evaluate the relationship between first-time lower respiratory tract infections and intestinal colonization of CRKP.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Carbapenem-Resistant Enterobacteriaceae Lower Respiratory Tract Infections

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18 years and above * CRKP is cultured from lower respiratory tract specimens in 15 days * Lower respiratory tract infection based on at least two of the followings: abnormal temperature (body temperature greater than 38.5°C or less than 36.5°C), leucocyte count abnormality (leucocyte count greater than 10\*10\^9/L or less than 4\*10\^9/L), and the presence of purulent tracheal secretions. Exclusion Criteria: * There are other bacteria that can produce carbapenemases exist in lower respiratory tract specimens * Infected with CRE before

Locations (1)

Outcomes

Primary Outcomes

The detection of the carbapenemase gene types produced by Klebsiella pneumoniae in rectal swabs and BALF by Xpert Carba-R

The investigators use the Xpert Carba-R to detect the carbapenemase gene types produced by Klebsiella pneumoniae in rectal swabs and bronchoalveolar lavage fluid (BALF) . The investigators will compare the consistency of results between the two specimens.

Time frame: Up to 2 weeks after each enrollment