Repurposing Siponimod for Alzheimer's Disease

Inclusion Criteria: 1. Male or female at least 50 years of age, but less than 85 (84 at time of screening) 2. Females must be of non-childbearing potential or have negative pregnancy test at time of screening. Women of non-childbearing potential are defined as women who are either permanently sterilized (hysterectomy, bilateral oophorectomy or bilateral salpingectomy) or who are postmenopausal. Women will be considered postmenopausal if they have been amenorrheic for \>=12 months prior to the planned date of enrollment. 3. Must have a diagnosis of mild Alzheimer\'s Dementia determined by medical record review. 4. Vision and hearing must be sufficient to comply with study procedures. Be able to take oral medications. 5. Must be able to attend all study visits indicated in the schedule of visits. 6. Must have a collateral informant/study partner who has significant direct contact with the patient at least 10 hours per week and who is willing to accompany the patient to specified clinic visits, supervise administration of all study medication, and be available for telephone visits/interviews. 7. Documented Mini Mental State Exam (MMSE) score between 21-26 at Screening Visit. 8. CT or MRI scan of the brain within 12 months of enrollment showing no evidence of significant focal lesions or other pathology which could contribute to dementia. If neither a CT nor an MRI scan is available from the past 12 months, a CT scan fulfilling the requirements must be obtained before randomization. 9. Hachinski ischemic score must be \< 4. 10. Geriatric depression scale must be \< 10. 11. Prior to dosing all randomized study subjects must show proof they have received immunization to varicella (VZV IgG). 12. If the patient has a legally authorized representative (LAR), the LAR must review and sign the informed consent form. If the patient does not have a LAR, the patient must appear able to provide informed consent and must review and sign the informed consent form. In addition, the patient's informant/study partner (as defined above) must sign an informed consent form. If the LAR and the patient's informant /study partner are the same individual, he/she should sign under both designations. Exclusion Criteria: 1. Taking one of the following medications: Medications for treatment of cancer or other drugs that weaken the immune system (ex. Natalizumab and Rituximab), Amiodarone, Bishydroxycoumarin, Chloramphenicol, Cimetidine, Fluconazole, Fluvastatin, Miconazole, Phenylbutazone, Sulphinpyrazone, Sulphadiazine, Sulphamethizole, Sulfamethoxazole, Sulphaphenazole, Trimethoprim, and Zafirlukast. 2. Current active infection in participants including, but not limited to, herpes zoster, herpes infection, bronchitis, sinusitis, upper respiratory infection and fungal skin infection. Siponimod may increase the risk in participants with active infections. 3. If participant received mRNA COVID-19 vaccination, must have received last dose at least 3 months prior to first dose of study drug/placebo. 4. Current evidence or history within the last 3 years of a neurological or psychiatric illness that could contribute to dementia, including (but not limited to) epilepsy, focal brain lesion, Parkinson's disease, seizure disorder, or head injury with loss of consciousness. 5. Meets DSM IV criteria for any major psychiatric disorder including psychosis, major depression and bipolar disorder. 6. Known history of self-reported alcohol and/ or substance abuse. 7. Isolated living circumstances which would prohibit a study partner from providing sufficient and credible information about the participant. 8. Poorly controlled hypertension 9. Known Atrioventricular heart block, known heart block type I-III. 10. History of myocardial infarction or signs or symptoms of unstable coronary artery disease within the last year (including revascularization procedure/angioplasty). 11. Severe pulmonary disease (including chronic obstructive pulmonary disease) requiring more than 2 hospitalizations within the past year. 12. Untreated obstructive sleep apnea. 13. Any thyroid disease (unless euthyroid on treatment for at least 6 months prior to screening). \[15\] Active neoplastic disease (except for skin tumors other than melanoma). Patients with a history of prior malignancy are eligible provided they were treated with curative intent and (i) do not require any longer any active therapy; (ii) being considered in complete remission; and (iii) after the Medical Monitor's assessment/approval of each case. 14. Prior prostate cancer or new diagnosis of prostate cancer. 15. History of multiple myeloma. 16. Absolute lymphocytopenia of \<1,000/mm3, or a history of lymphocytopenia. 17. Absolute neutropenia of \<1,000/mm3, or a history of neutropenia. 18. History of/ or current thromboembolism (including deep venous thrombosis). 19. Any clinically significant hepatic or renal disease (including presence of Hepatitis B or C surface antigen or an elevated transaminase levels of greater than 2x the upper limit of normal (ULN) or creatinine greater than 1.5 x upper limit of normal (ULN)). 20. Clinically significant hematologic or coagulation disorder including any unexplained anemia, or a platelet count less than 100,000/μL at screening. 21. Use of any investigational drug within 30 days or within five half-lives of the investigational agent, whichever is longer. 22. Unwilling or unable to undergo CT or MRI imaging. 23. In the opinion of the investigator, participation would not be in the best interest of the subject.