The primary purpose of this study is to compare the safety and effectiveness of commercially available dietary supplements believed to increase coenzyme Q10 (CoQ10) concentrations. An 8-week, randomized, placebo-controlled clinical trial will be conducted comparing the effectiveness of four commercially available dietary supplements on increasing CoQ10 concentrations and self-reported health outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
150
Combination of ubiquinol and geranylgeraniol
Geranylgeraniol alone
Ubiquinol alone
True Health Center for Precision Medicine
El Dorado Hills, California, United States
Cornerstone Health Community
Centennial, Colorado, United States
CTMD Research
Palm Springs, Florida, United States
Functional Medicine of Idaho
Eagle, Idaho, United States
Plasma Coenzyme Q10
Time frame: Baseline and 8 weeks
Comprehensive metabolic panel
Alanine aminotransferase (ALT) in units per liter (U/L)
Time frame: Baseline and 8 weeks
Lipid panel
Low-density lipoprotein (LDL) in milligrams per deciliter (mg/dL)
Time frame: Baseline and 8 weeks
Patient-Reported Outcomes Measurement Information System (PROMIS) - Global Health
Raw scores range from 4 to 20, with higher scores indicating better global physical or mental health compared to the average
Time frame: Baseline and 8 weeks
Profile of Mood States - Vigor Subscale
Scores range from 0 to 32, with higher scores indicating better energy levels
Time frame: Baseline and 8 weeks
Short Form 36 (SF-36) - Vitality Subscale
Scores range from 0 to 100, with higher scores indicating greater vitality
Time frame: Baseline and 8 weeks
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Ubiquinone alone
Placebo capsule
New Dawn Wellness and Medical Center
Houston, Texas, United States
Vida Integrated Health
Seattle, Washington, United States