Reference Values and Determinants of 6-minute Walk Test

Functional ambulation scale (FAC)

Patients will be classified by walking ability using FAC has six levels (0 to 5) that are classified according to the walking ability on the basis of the amount of physical support required, which are as follows: nonfunctional ambulatory(FAC 0); ambulatory, continuous manual contact to support body weight as well as to maintain balance or to assist coordination (FAC 1); ambulatory \[level I\], intermittent or continuous light touch to assist balance or coordination (FAC 2); ambulatory, dependent on supervision (FAC 3); ambulatory, independent, level surface only (FAC 4); and ambulatory, independent (FAC 5).

Time frame: through study completion, an average of one month

Brunnstrom motor recovery staging

Upper extremity, hand and lower extremity motor recovery will be assessed using the Brunnstrom 6 sequential stages of motor recovery.

Time frame: through study completion, an average of one month

Modified Ashworth Scale (MAS)

The Modified Ashworth Scale will be used to measure the severity of knee extensor, knee flexor and ankle plantar flexor spasticity. MAS scores will be added together to give a total MAS score. MAS is graded from 0 to 4. A score of 0 indicates no increase at all in muscle tone, and 4 indicates that the joint is rigid in flexion or extension.

Time frame: through study completion, an average of one month

Beck depression inventory (BDI)

The beck depression inventory (BDI) will be used to evaluate depression. The BDI consists of 21 questions about how the subject has been feeling in the last week. Each question has a set of at least four possible answers, ranging in intensity. A value of 0-3 is assigned for each answer, and the total score is compared with a key to determine the severity of depression .The standard cut off values are as follows: 0-9, minimal depression; 10-18, mild depression; 19-29, moderate depression; and 30-63, severe depression.