Proteomic Analysis on Myopic Children Using Orthokeratology Lenses With Good or Poor Myopic Control

N/AActive Not RecruitingNCT06647472

Vejle Hospital20 enrolled

Overview

The key objective of the study is to gain an understanding of the biochemical processes that contribute to orthokeratology lenses being more effective in specific individuals compared to others. With this knowledge, we hope to optimize treatment effectiveness in those currently experiencing less favorable outcomes from treatment in the future. The primary aim is to investigate differences in protein levels in children using orthokeratology lenses with various effects of myopia control. Hypothesis: There is a significant difference in the expression of molecules in children with various effects of myopia control.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myopia Healthy Orthokeratology

Eligibility

Sex: ALLMin age: 5 YearsMax age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children treated with orthokeratology lenses. * Children on or above the 95th percentile of myopia growth curves for European children at the time of treatment initiation. * Treatment and follow-up duration ≥ 6 months. Exclusion Criteria: * Current use of eye drops. * Objective signs of dry eyes on slit-lamp examination. * Active eye infection.

Locations (1)

Outcomes

Primary Outcomes

Difference in protein levels measured by mass spectrometry label-free quantification (LFQ) between children using orthokeratology lenses with different levels of myopia control effectiveness

Time frame: At baseline