High Interval Versus Moderate Intensity Continuous Training on Soluble st2 Biomarkers in Chronic Heart Failure

Cairo University60 enrolled

Overview

This study was designed to compare between the effect of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on soluble ST2 biomarkers among chronic heart failure patients, also measure the improvement in the quality of life with different modes of exercise and with of it is more benifitial for the heart failure patient

The data concerned with the study including soluble ST2 biomarker levels, ejection fraction and MLHFQ was measured before and after twelve weeks of treatment.In this study a total sixty male patients with chronic heart failure NYHA class (I \&II) were selected from the outpatient clinic, El-Demerdash hospital, Ain-shams University. Their age ranged from 50-60 years. Patients were randomly assigned into two groups, group A receiving HIIT along with prescribed medical treatment and group B receiving MCT along with prescribed medical treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Heart Failure

Interventions

HIITSOTHER

Frequency: HIIT will be in 2 supervised sessions per week for 12 weeks on the treadmill. session duration from 30-40 min including the waming up and cooling down Intensity: HIIT included 4 minute intervals aiming 60-85% of heart rate reserve

MICTOTHER

Frequency: Moderate continuous training is scheduled 2 times per week for 12 weeks. Intensity: exercise had been applied on the treadmill with 40%-59% of heart rate reserve) session duration from 30-40 min including the warming up and cooling down

Eligibility

Sex: MALEMin age: 50 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patients selection was according to the following criteria: * Patients diagnosed with chronic heart failure (New York heart association class I\& II) with systolic left ventricular dysfunction. * Their left ventricular ejection fraction (LVEF) \<40%. * Medical treatment was optimized at least three months prior to study entry. * All patients didn't participate in any rehabilitation programs prior to the study. Exclusion Criteria: * Patients who had met one of the following criteria were excluded from the study: 1. Signs of acute heart failure, unstable angina or severe arrhythmia three months prior to enrolment in the study. 2. Pacemakers. 3. Chronic obstructive pulmonary disease. 4. Other disorders counteracting exercise testing conditions that limit lower limb mobility (for example, burns, fractures) 5. Pre-existing neuromuscular diseases (for example Myasthenia Gravis).

Locations (1)

Faculty of physical therapy Cairo University

Giza, Egypt

Outcomes

Primary Outcomes

soluble ST2 biomarker level

sample was taken at the cubited vein at the beginning of the program and also at its end

Time frame: before the start of the trail and at the end of the trail 3 months

Secondary Outcomes

ejection fraction

Left ventricular systolic dysfunction was assessed using the ejection fraction by 2D simpson method

Time frame: before the start of the trail and at the end of the trail 3 months

mannisota of daily living questionnaire score

The twenty one item questionnaire was usedfrom 0 (none) to 5 (very much). It provides a total score (range 0-105, from best to worst HRQoL), as well as scores for two dimensions, physical (8 items, range 0-40) and emotional (5 items, range 0-25). The other eight items (of the total of 21) are only considered for the calculation of the total score.

Time frame: before the start of the trail and at the end of the trail 3 months

peak exercise response

monitoring the peak exercise response

Time frame: before the start of the trail and at the end of the trail 3 months

Data from ClinicalTrials.gov

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