A Study of Olanzapine-Samidorphan Tablets in Adults With Schizophrenia

Inclusion Criteria: * Subject is age 18 to 55 years, inclusive. * Subject has a BMI of 18.0 to 30.0 kg/m2, inclusive. * Subject meets the DSM-5 criteria for a primary diagnosis of schizophrenia. * PANSS total score ≥ 70. Exclusion Criteria: * Diagnosis of schizoaffective disorder or bipolar I or II disorder, or current, untreated or unstable major depressive disorder, or any other psychiatric condition that could interfere with participation in the study. * Subject poses a current suicide risk in the opinion of the investigator. * Subject has inflammatory bowel disease or any other gastrointestinal disorder associated with weight loss, anorexia nervosa, or binge eating disorder. * Subject has a history of diabetes. * Subject has used olanzapine, clozapine, chlorpromazine, or thioridazine at any time during the 6 months prior to screening or long-acting injectable antipsychotic medication in the last 6 months. * Subject has taken opioid agonists within the 14 days prior to screening and/or anticipates a need to take opioid medication during the study period, or has taken opioid antagonists within 60 days prior to screening. * Subject is taking any weight loss agents or hypoglycemic agents at screening. * Subject has had a surgical procedure for weight loss or is planning to have liposuction during the study. * Subject has a clinically significant or unstable medical illness, condition, or disorder that would be anticipated to potentially compromise subject safety or adversely affect the evaluation of efficacy.