Femtosecond laser-assisted cataract surgery is rapidly gaining popularity. Among the 5 femtosecond laser platforms available at present for cataract surgery, the Femto LDV Z8 (Ziemer Ophthalmic Systems AG) is a high-frequency system and delivers energy pulses in nanojoule levels, while Lensx platform (Lensx, Alcon Laboratories, Inc.) used a high-energy laser system. In femtosecond laser-assisted cataract surgery, the laser pretreatment is associated with breakdown of blood-aqueous barrier (BAB) associated with increased aqueous total prostaglandin, cytokines and Oxygen-free radicals concentration. The prostaglandin rise immediately after laser pretreatment is further thought to be the causative factor for the intraoperative miosis in femtosecond laser-assisted cataract surgery. However, the analysis of anterior chamber inflammatory factors, oxidative stress, and pupil size after femtosecond laser-assisted cataract surgery between different laser platforms has not been investigated in clinical studies. Understanding the cytokine and chemokine changes related to the laser pretreatment provides better insight into the inflammatory response in femtosecond laser-assisted cataract surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Enrollment
80
ye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
PGE2
The concentrations of PGE2 in aqueous humor
Time frame: through study completion, an average of half a year
cytokines (IL-1β、IL-6, IL-8、TNF-a)
The concentrations of cytokines (IL-1β、IL-6, IL-8、TNF-a) in aqueous humor
Time frame: through study completion, an average of half a year
MDA
The concentrations of MDA in aqueous humor
Time frame: through study completion, an average of half a year
central corneal thickness
The central corneal thickness was measured
Time frame: through study completion, an average of half a year
central macular thickness
The central macular thickness was measured
Time frame: through study completion, an average of half a year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.