The goal of this observational study is to the early impacts of psychosis and antipsychotic medications on brain metabolism in young adults recently diagnosed with a first episode of psychosis. The main question aims to evaluate the effect of 4 to 6 weeks of antipsychotic medication on brain metabolism measured by PET scan (cerebral uptake of 11C-Acetoacetate + 18 Fluorodeoxyglucose). Participants will undergo a multimodal imaging protocol with other measures of psychopathology (e.g., cognition, depressive symptoms, etc.) and (metabolic marker, inflammation, etc).
Study Type
OBSERVATIONAL
Enrollment
18
Any Antipsychotic drugs prescripbe as standrd of care for this specific populaton
Hotel-Dieu CIUSSS de l'Estrie-CHUS
Sherbrooke, Quebec, Canada
Cerebral metabolic rate of glucose and acetotacetate
Cerebral metabolic rate of glucose and acetotacetate(μmol/100 g/min) quantified with PET scan with 18F-FDG tracer and 11C-AcAc
Time frame: BEFORE introduction of antipsychotic medicationand AFTER 4 to 6 weeks
Net inflow of glucose and acetoacetate
Net inflow of glucose and acetoacetate (k) as measured by PET scan with 18F-FDG and 11C-AcAc traceur (Kglu and Kacac, min-1)
Time frame: BEFORE introduction of antipsychotic medicationand AFTER 4 to 6 weeks
% of change in Brief Psychiatric Rating Scale
% of change in the Brief psychiatric Rating Scale (raw score after/raw score before\*100)
Time frame: BEFORE introduction of antipsychotic medicationand AFTER 4 to 6 weeks
Concentration of glucose
Concentration of glucose measure in fasting plasma
Time frame: BEFORE introduction of antipsychotic medicationand AFTER 4 to 6 weeks
Concentration of insuline
Concentration of insulinemeasure in fasting plasma
Time frame: BEFORE introduction of antipsychotic medicationand AFTER 4 to 6 weeks
Concentration of Hemoglobin A1C
Concentration of HbA1C measured in fasting plasma
Time frame: BEFORE introduction of antipsychotic medicationand AFTER 4 to 6 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.