Chemical Debridement and Leg Ulcers

Inclusion Criteria: * Participants with a venous leg ulcer or mixed aetiology ulcer. * Duration of wound ≥ 6 weeks ≤ 5 years * Wound is ≥ 5 cm2 ≤ 200cm2 * Presence of at least 25% visible slough within the wound bed * The Participant must be able to understand the study and provide written informed consent * No clinical signs of infection Exclusion Criteria: * Known hypersensitivity or contraindications to any of the wound treatments, dressings or compression bandaging to be used in the trial * Current local or systemic antibiotics in the week prior to inclusion * Clinically infected wound as determined by the presence of 3 or more of the following clinical signs: perilesional erythema, pain between two dressing changes, malodorous wound, abundant exudate and oedema * Prolonged treatment with immunosuppressive agents or high dose corticosteroids * Participants who have a current illness or condition which may interfere with wound healing in the last 30 days (carcinoma, connective tissue disease, autoimmune disease or alcohol or drug abuse) * Participants who have participated in a clinical trial on wound healing within the past month * Participants with a known history of non- adherence with medical treatment