Effect of Akkermansia Muciniphila Akk11 on Metabolic and Gut Health in Overweight and Obese Subjects

Inclusion Criteria: 1. 18-45 years old; 2. BMI ≥ 24 kg/m2 or men with a body fat percentage of ≥ 25% and women with a body fat percentage of ≥ 30%； 3. Normal liver function indexes; 4. Willing to complete study-related questionnaires and diaries and complete all clinical visits. Exclusion Criteria: 1. Those who have been diagnosed with high uric acid or gout are not recommended to participate in the test; 2. Psychiatric or neurological diseases, celiac disease, lactose intolerance, allergies; 3. Have the following diseases: irritable bowel syndrome, ulcerative colitis, fatty liver, liver cirrhosis, etc.; 4. Recently treated with antibiotics (i.e., \< 3 months prior to the start of the study); 5. Participants who smoked more than 10 cigarettes per day were excluded; 6. It is not recommended to participate in other special circumstances, such as those who are allergic to probiotic products; 7. Pregnant and lactating women are not suitable for experiments.