The investigators evaluated the impact of AF on different subtypes of post-alteplase hemorrhagic transformation of brain infarction.
Investigators conducted a prospective cohort study between July 2021 and July 2023. They screened 1550 patients who presented with AIS and received alteplase and included 716 AIS patients who met the inclusion criteria and were diagnosed based on a thorough clinical assessment, including a detailed medical history, physical examination, and specific brain imaging results and treated with alteplase within four and half hours of stroke onset. The investigators assessed the patients' follow-up brain imaging to detect the subtypes of hemorrhagic transformation after receiving alteplase. The study consisted of two distinct groups. The first group consisted of 454 patients who did not experience hemorrhagic infarction, while the second group comprised 262 patients who experienced hemorrhagic infarction. The investigators evaluated whether the characteristics of ischemic stroke patients, door-to-needle time, and stroke risk factors different types of AF were predictive variables for different subtypes of post-alteplase hemorrhagic transformation of brain infarction.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
716
Following the guidelines set by the American Heart Association/American Stroke Association (AHA/ASA), inclusion and exclusion criteria for alteplase were established; 0.9 mg/kg of alteplase up to a maximum dose of 90 mg was administered intravenously to eligible individuals within 4.5 hours of the beginning of their clinical manifestations (10% bolus, 90% infusion in 1 hour). After receiving IV-alteplase, all patients continued their management and rehabilitation in the stroke unit
Following the guidelines set by the American Heart Association/American Stroke Association (AHA/ASA), inclusion and exclusion criteria for alteplase were established; 0.9 mg/kg of alteplase up to a maximum dose of 90 mg was administered intravenously to eligible individuals within 4.5 hours of the beginning of their clinical manifestations (10% bolus, 90% infusion in 1 hour). After receiving IV-alteplase, all patients continued their management and rehabilitation in the stroke unit
Kafr Elsheikh University Hospital
Kafr ash Shaykh, Egypt
RECRUITINGthe rate of each AF type in the hemorrhagic infarction type 1 group compared to non HT group
The investigators will evaluate the rate of each AF type in the hemorrhagic infarction type 1 group compared to non HT group
Time frame: 48 days
the rate of each AF type in the hemorrhagic infarction type 2 group compared to non HT group
The investigators will evaluate the rate of each AF type in the hemorrhagic infarction type 2 group compared to non HT group
Time frame: 48 hours
the rate of each AF type in the parenchymal haematoma type 1 group compared to non HT group
The investigators will evaluate the rate of each AF type in the parenchymal haematoma type 1 group compared to non HT group
Time frame: 48 hours
the rate of each AF type in the parenchymal haematoma type 2 group compared to non HT group
The investigators will evaluate the rate of each AF type in the parenchymal haematoma type 2 group compared to non HT group
Time frame: 48 hours
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