RCT on the Performance and Safety of LightForce® Therapy Lasers on Knee Osteoarthritis Pain Reduction (SPARK)

Inclusion Criteria: * Patient male or female with age ≥18 years old * Patient with radiographic diagnosis of knee osteoarthritis (as confirmed by x- ray or CT scan) to be treated by LightForce® Therapy Lasers according its indications. * Patient with Kellgren and Lawrence grade 2-3 unilateral or bilateral knee osteoarthritis * Patient suffering from knee osteoarthritis pain for more than 6 months prior to enrollment * Pain (either persistent or during activities) score reported by the subject at baseline ≥ 40 mm measured on VAS * Patient able to provide written informed consent * Patient with BMI ≤30 kg/m2 * For FRANCE ONLY: To be affiliated to the social security system or to be beneficiary of such system Exclusion Criteria: * Patient with musculoskeletal pathological conditions not to be treated with/contraindication to the use of LightForce® Therapy Lasers according to its intended use and indications * Patients who are taking drugs that have heat or light sensitive contraindications, such as but not limited to certain types of steroids * Patients who are administered with corticosteroids, should discontinue the treatment at least 2 weeks prior to study treatment start * Pregnant females or females of childbearing potentially planning to become pregnant during the study participation * Patients who had inflammatory arthritis (i.e. rheumatoid arthritis, psoriatic arthritis) * Patients who underwent intra-articular injection (Ialuronic acid, platelet rich plasma or corticosteroids) in the knee in the last 6 months * Patients who have a disease that would limit their participation in exercises (i.e. severe chronic obstructive pulmonary disease, severe heart failure, cerebrovascular event history) * Patients who have hip or ankle/foot joint pathology that might interfere with participation in exercises/knee recovery * Patients with a diagnosis of active cancer * Patients with tattoos covering more than 30% of the area to be treated with LightForce® Therapy Lasers * Patients who are mentally or physically incapacitated * Patient participating in other clinical study or has completed a clinical study less than 30 days prior to enrollment * Patients with other musculoskeletal problems of the knee joint such as tendon or ligament injury, recent surgery, recent fracture, or recent meniscus injury and/or undergoing to specific physiotherapy for these ("recent" is defined as within 30 days prior to enrollment) * Patients with other clinically significant co-morbidities that make the patient unsuitable for study participation, at the discretion of the investigator.