Salmeterol Effect on Exercise Performance

University of Copenhagen36 enrolled

Overview

The purpose of the project is to investigate the muscle anabolic response to acute beta2-adrenergic stimulation in young healthy men and women.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Healthy

Interventions

SalmeterolDRUG

Participants are administered 200 µg salmeterol (8 puffs) from a MDI device

PlaceboDRUG

Participants are administered placebo (8 puffs) from a MDI device

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Inclusion Criteria: * Age 18-40 * Physically active \>5 hours a week * Maximum oxygen uptake classified as high or very high Exclusion Criteria: * Active smoker currently or within the past 5 years * Regular intake of medication deemed by the responsible study physician to affect the test parameters (hormonal contraception is accepted for women) * Chronic or acute illness deemed by the responsible study physician to affect the test parameters * Deviation from the study protocol * Lean mass index \>21 kg/m² * Pregnancy * Smoker * Blood donation during the past 3 months

Locations (1)

August Krogh Building

Copenhagen, Denmark

RECRUITING

Outcomes

Primary Outcomes

Power output during sprint testing

Power output measured in Watts during a sprint on a bike ergometer

Time frame: Through study completion, an average on 2 weeks

Secondary Outcomes

Power output during time trial

Mean power output measured in Watts during a time trial on a bike ergometer

Time frame: Through study completion, an average on 2 weeks

Data from ClinicalTrials.gov

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