The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

Sohag University32 enrolled

Overview

To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Open Heart Sugery Neuronal Damage

Interventions

DexmedetomidineDRUG

Dexmedetomidine infusion during open heart surgery

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of both sexes undergoing elective open-heart surgery Exclusion Criteria: * Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval. Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education

Locations (1)

Sohag University

Sohag, Egypt

RECRUITING

Outcomes

Primary Outcomes

postoperative cognitive function

using the Mini-Mental State Examination (MMSE) to evaluate cognitive status

Time frame: pre- oprerative , Mini-mental state examination (MMSE) will be performed at 1, 3 and 7 days after operation.

Secondary Outcomes

serum Neuron Specific Enolase levels

serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgeries.

Time frame: pre-operative ,post-operative 12 hours

Data from ClinicalTrials.gov

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