The Effects of Dexmedetomidine on Postoperative Cognitive Function in Open Heart Surgery

Sohag University32 enrolled

Overview

To assess the impact of Dexmedetomidine on postoperative cognitive function and serum Neuron Specific Enolase levels as an indicator of neuronal injury in patients undergoing open heart surgery

This randomized controlled study was conducted to evaluate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing elective open-heart surgery. Patients were randomly assigned into two groups: a dexmedetomidine group receiving intravenous dexmedetomidine infusion during surgery and a control group receiving normal saline infusion as placebo in addition to standard anesthesia. Postoperative cognitive function was assessed using the Mini-Mental State Examination (MMSE). Serum neuron-specific enolase (NSE) levels were measured as a biomarker of neuronal injury. Intraoperative depth of anesthesia was monitored using the bispectral index (BIS). The aim of the study was to investigate whether dexmedetomidine administration could reduce postoperative cognitive dysfunction and neuronal injury in patients undergoing cardiac surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Cardiac Surgery Postoperative Cognitive Dysfunction Neurologic Manifestations

Interventions

DexmedetomidineDRUG

Dexmedetomidine infusion during open heart surgery

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients of both sexes undergoing elective open-heart surgery Exclusion Criteria: * Patients with a history of neurological disorders, severe renal or liver dysfunction, or contraindications to Dexmedetomidine as in patients with known QT prolongation, a history of other arrhythmias, symptomatic bradycardia, hypokalemia, or hypomagnesemia, and in patients receiving other drugs known to prolong the QT interval. Patients with cognitive impairment, mental and psychological illness and chronic alcoholics, drug addicts, abuse of psychotropic substances, illiterate education

Locations (1)

Sohag University

Sohag, Egypt

Outcomes

Primary Outcomes

Postoperative cognitive function

Cognitive function will be evaluated using the Mini-Mental State Examination (MMSE).

Time frame: Preoperative baseline, and at 1 day, 3 days, and 7 days after surgery

Secondary Outcomes

Serum neuron-specific enolase levels

Serum neuron-specific enolase levels will be measured as a biomarker of neuronal injury.

Time frame: Preoperative baseline and 12 hours after surgery

Data from ClinicalTrials.gov

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