Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses

Jessica Rigutto46 enrolled

Overview

Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin, as well as its protein characteristics, following the administration of a single iron dose

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Iron Deficiency (Without Anemia)

Interventions

40mg oral iron dosingDIETARY_SUPPLEMENT

Participants will receive a single morning oral dose of iron as Fe57-labelled ferrous sulfate

100mg oral iron dosingDIETARY_SUPPLEMENT

Participants will receive a single morning oral dose of iron as Fe57-labelled ferrous sulfate

180mg oral iron dosingDIETARY_SUPPLEMENT

Participants will receive a single morning oral dose of iron as Fe57-labelled ferrous sulfate

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Low iron stores (SF levels \< 30 µg/L), * no anemia (Hb \> 120 g/L) * no inflammation (CRP \< 5 mg/L) * 18 to 45 years old. * Body weight \<70 kg * Normal body Mass Index (18.5-26.5 kg/m2) Exclusion Criteria: * Any chronic or acute disease * Consumption of mineral and vitamin supplements since screening and over the study period * Blood transfusion, blood donation or significant blood loss over the past 6 months, * Pregnant or breastfeeding, * Continuous/long-term use of medication during the whole studies (except for contraceptives) * Therapeutic iron infusion over the past 6 months, * Known hypersensitivity or allergy to iron supplements, * Intention to become pregnant over the course of the study

Locations (2)

ETH Zurich

Zurich, Canton of Zurich, Switzerland

Laboratory of Nutrition and Metabolic Epigenetics

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Serum ferritin

Serum ferritin concentration

Time frame: study day 1

Serum ferritin

Serum ferritin concentration

Time frame: study day 7

Secondary Outcomes

C-reactive protein

C-reactive protein concentration in serum

Time frame: study day 0

Serum ferritin

Serum ferritin concentration

Time frame: study day 0

Serum ferritin

Serum ferritin concentration

Time frame: study day 6

Serum ferritin

Serum ferritin concentration

Time frame: study day 14

Serum ferritin

Serum ferritin concentration

Time frame: study day 5

Serum ferritin

Serum ferritin concentration

Time frame: study day 4

Serum ferritin

Serum ferritin concentration

Time frame: study day 3

Serum ferritin

Serum ferritin concentration

Time frame: study day 2

Data from ClinicalTrials.gov

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