The goal of this observational study is to gather more information on kidney oxygen levels in babies with a patent ductus arteriosus (PDA), and evaluate the relationships between kidney oxygen levels, PDA status and kidney injury. Researchers will do this by looking at ultrasound images of the heart, analyzing substances in the urine, and evaluating oxygen levels in the kidneys.
Study Type
OBSERVATIONAL
Enrollment
45
Application of regional NIRS sensors to brain and kidney sites in the first 72 hours after birth to monitor regional tissue oxygenation.
Meriter Hospital, Inc.
Madison, Wisconsin, United States
RECRUITINGComparison of patent ductus arteriosus (PDA) echocardiography parameters to kidney hypoxia
Measured through continuous renal near infrared spectroscopy (NIRS) monitoring in neonates with a PDA to those without. Echos will be obtained every 48 hours during the first 7 days of age for a maximum of 3. RSO2 will be recorded until 7 days of age.
Time frame: Days 1 to 7 of age
Correlation of Iowa PDA score to kidney hypoxia
The Iowa PDA score will be classified as low (0-3), moderate (4-6), or high volume (\>6) for each echo obtained. Lower scores are optimal. RSO2 correlation will be made with PDA score during the first 7 days of age.
Time frame: Days 1-7 of age
Correlation between urinary biomarkers and Iowa PDA score
The Iowa PDA score will be classified as low (0-3), moderate (4-6), or high volume (\>6). Urinary NGAL, cystatin C, and beta 2 micro globulin levels will be measured daily for the first 7 days of age and a correlation with the Iowa PDA score to levels of these biomarkers will be made.
Time frame: Days 1-7 of life
Correlation between rates of hypertension and Iowa PDA score
The Iowa PDA score will be classified as low (0-3), moderate (4-6), or high volume (\>6). Hypertension will be assessed for throughout hospitalization and a correlation with Iowa PDA score and the diagnosis of hypertension will be made.
Time frame: Duration of hospitalization, up to 6 months
Correlation between rates of acute kidney injury (AKI) and Iowa PDA score
The Iowa PDA score will be classified as low (0-3), moderate (4-6), or high volume (\>6). The diagnosis of AKI will be made using either or both urine output criteria or serum creatinine criteria and a correlation will be made with the IOWA PDA score in the first 7 days of age.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Duration of hospitalization, up to 6 months