A Cohort Study on the Efficacy of Bariatric Surgery for Rapidly Progressing Diabetic Nephropathy

China-Japan Friendship Hospital100 enrolled

Overview

Establish a cohort of diabetic kidney disease(DKD) patients with intensive weight loss treatment to evaluate the impact of intensive weight loss treatment on the renal prognosis of DKD and construct a prediction model for the improvement of renal outcomes after weight loss.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Bariatric Surgeries Diabetic Nephropathy

Interventions

Bariatric surgeryPROCEDURE

Laparoscopic sleeve gastrectomy or laparoscopic gastric bypass based on β-cell function

Non-surgical therapyOTHER

Diet management，exercise，metformin，GLP-1 receptor agonists and other drugs which can lose weight.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 to 65 years old; * BMI\>25Kg/m2 or abdominal obesity (i.e. waist circumference\>90cm for men and\>85cm for women); * eGFR\<30ml/min/1.73m2 or urinary microalbumin≥300mg/g, eGFR\<60ml/min/1.73m2. Exclusion Criteria: * Patients who are taking glucocorticoids; * Combined with tumors; ③Combined with autoimmune diseases; ④Serum albumin\<25g/L.

Locations (1)

China-Japan Friendship Hospital

Beijing, Beijing Municipality, China

RECRUITING