Cognitive Effects Associated With Hippocampal Neurogenesis Induced by ECT in the Treatment of Depression

Inclusion Criteria: 1. Study population: depressed subjects treated with ECT * Male or female over 18 years of age * Hospitalised at the Centre Hospitalier Sainte-Anne * Suffering from a unipolar or bipolar major depressive episode, according to DSM5 criteria * Indication for ECT treatment * Patient has given informed written consent * Beneficiary of a social security scheme 2. Control population: depressed subjects treated without ECT * Male or female over 18 years of age * Hospitalised at the Centre Hospitalier Sainte-Anne * Suffering from a unipolar or bipolar major depressive episode, according to DSM5 criteria * Patient who has given informed written consent * Beneficiary of a social security scheme 3. Control population: healthy volunteers * Male or female over 18 years of age * Patient with written informed consent * Beneficiary of a social security scheme Exclusion Criteria: 1. Study population: depressed subjects with ECT * Psychiatric comorbidity: schizophrenia, pervasive developmental disorder, dependence on a substance other than tobacco * Neurological comorbidity: Parkinson's disease, dementia * ECT treatment in the 6 months prior to inclusion * Compulsory care * Protected adults, persons under court protection measures * Persons deprived of liberty by judicial or administrative decision; * Refusal of consent to ECT treatment * Contraindications to ECT (HTIC, recent history of stroke, severe uncontrolled arterial hypertension, contraindication to anaesthesia) * Contraindications to MRI (patients with metal prostheses, claustrophobia) * Pregnant or breast-feeding women 2. Control population: depressed subjects without ECT * Psychiatric comorbidity: schizophrenia, pervasive developmental disorder, dependence on any substance other than tobacco * Neurological comorbidity: Parkinson's disease, dementia * ECT treatment in the 6 months prior to inclusion * Compulsory care * Protected adults, persons under court protection measures * Persons deprived of liberty by judicial or administrative decision; * Pregnant or breast-feeding women 3. Control population: healthyvolunteers * Protected adults, persons under legal protection, * Persons deprived of their liberty by judicial or administrative decision ; * persons hospitalised for purposes other than research * Clear psychiatric history * Dependence on any substance other than tobacco * Neurological history: Parkinson's disease, dementia * Pregnant or breast-feeding women