The goal of this observational study is to explore the relationship between iron-deficiency anemia and neurobehavioral development in children aged 6-24 months. This study focuses on children who undergo health check-ups and blood tests at pediatric health clinics in Pingshan District, Shenzhen, China. The main questions it aims to answer are: How does iron-deficiency anemia affect children's neurobehavioral development, including motor skills, language ability, and social behavior? How does anemia influence growth and nutrition, such as weight, height, and body mass index (BMI) in children? Participants will: Undergo blood tests (including hemoglobin levels, serum ferritin, and serum iron) to assess anemia status. Be assessed using the "Neuropsychological Behavioral Development Scale for Children Aged 0-6" to measure motor, cognitive, language, and social development. Provide general health information, such as birth history, feeding methods, and parental details, through interviews with trained surveyors. Researchers will compare children with and without iron-deficiency anemia to determine differences in neurobehavioral outcomes and development levels. The findings aim to provide evidence for early interventions to prevent the negative impacts of anemia and support children's healthy development.
Study Type
OBSERVATIONAL
Enrollment
1,000
Shenzhen Pingshan District Maternity & Child Healthcare Hospital, Department of Child Healthcare
Shenzhen, China/Guangdong, China
RECRUITINGNeurobehavioral Development Score
This measure assesses neurobehavioral development, including motor skills, language, social behavior, and adaptability, using the "Neuropsychological Behavioral Development Scale for Children Aged 0-6." The score is used to determine the developmental status of children in both the iron-deficiency and non-anemic groups.
Time frame: Baseline assessment and follow-up at 6 months.
Hemoglobin (Hb)
To assess the severity of anemia.
Time frame: Blood samples will be taken at baseline and follow-up at 3 months.
Serum Ferritin
To evaluate the iron stores in the body
Time frame: Blood samples will be taken at baseline and follow-up at 3 months
Physical Growth (Height)
This measure evaluates the physical growth of children, specifically tracking changes in height. Growth data will be compared between children with iron-deficiency anemia and those without to assess the impact of anemia on physical development.
Time frame: Baseline assessment and follow-up at 6 months.
Physical Growth ( Weight)
This measure evaluates children's changes in weight. Weight data will be compared between children with and without iron-deficiency anemia to assess anemia's impact on their physical development.
Time frame: Baseline assessment and follow-up at 6 months.
Physical Growth (BMI)
This measure assesses children's physical growth by tracking changes in BMI. BMI (Body Mass Index) is calculated by dividing a child's weight (kg) by the square of their height (m²). BMI values will be compared between children with and without iron-deficiency anemia to evaluate anemia's impact on physical development.
Time frame: Baseline assessment and follow-up at 6 months.
Eating behavior
Eating behavior was assessed using the Children's Eating Behaviour Questionnaire (CEBQ), which evaluates various aspects of children's eating habits, such as food responsiveness, enjoyment of food, and satiety responsiveness. The CEBQ scores will be compared between children with and without iron-deficiency anemia to evaluate how anemia might impact their eating behavior and, in turn, their physical development.
Time frame: Collected at baseline.
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