Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health

The Affiliated Hospital of Hangzhou Normal University350,000 enrolled

Overview

The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is: 1. How do meteorological factors and air pollution affect cardiovascular system? 2. What is the interaction between meteorological factors and air pollution on cardiovascular system? Participants will: 1. Provide their health data obtained in physical examination, including but not limited to blood pressure, blood routine, urine routine and B-ultrasound. 2. agree that the research team will use their personal identification number, gender, age, education level and other information for statistical analysis of the data.

The collected data include: ID number (or unique identification code similar to ID number), physical examination date, work unit, occupation, gender, age, systolic blood pressure, diastolic blood pressure, height, weight, blood routine, urine routine and blood biochemical examination results,Color Doppler (or B-ultrasound) examination results (thyroid color Doppler, abdominal color Doppler, urinary color Doppler, cardiac color Doppler, cervical vascular color Doppler, etc.), electrocardiogram, cardiac CTA, carbon 13 breath test, and written diagnosis results of liver fibrosis.

Study Type

OBSERVATIONAL

Enrollment

350,000

Conditions

Cardiovascular System Health

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: ·Relevant records in the physical examination database shall be ≥3 times ·≥18 years old Exclusion Criteria: * Relevant records in the physical examination database shall be ≥３times * Serious heart and lung diseases * Malignant tumors * Serious mental illness in the past

Outcomes

Primary Outcomes

Troponin

Troponin data were obtained by blood biochemical detection data recorded in the diagnosis and treatment system, with unit of µg/L.

Time frame: The troponin data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Blood pressure

Blood pressure data were obtained from the diagnosis and treatment record system and analyzed by standard sphygmomanometer, with unit of mmHg.

Time frame: The blood pressure data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Secondary Outcomes

Left ventricular ejection fraction（LVEF）

Left ventricular ejection fraction（LVEF）data were obtained by Cardiac color ultrasound data recorded in the diagnosis and treatment system, with unit of %

Time frame: The left ventricular ejection fraction（LVEF）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

White cell count

White cell count data were obtained by blood routine blood data recorded in the diagnosis and treatment system, with unit of 10\^9/L

Time frame: The white cell count data were tested at baseline 3 months before exposure to meteorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Controlled Attenuation Parameter（CAP）

Controlled Attenuation Parameter（CAP）data were obtained by Diagnosis of hepatic fibrosis data recorded in the diagnosis and treatment system, with unit of dB/m.

Time frame: The Controlled Attenuation Parameter（CAP）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

ST segment of electrocardiogram

ST segment were obtained by Electrocardiogram (ECG) recorded in the diagnosis and treatment system with unit of mV.

Time frame: The ST segment of electrocardiogram were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Degree of coronary artery stenosis

Degree of coronary artery stenosis data were obtained by Coronary CTA data recorded in the diagnosis and treatment system, with unit of µg/L

Time frame: The degree of coronary artery stenosis data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Weight

Weight data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of kg

Time frame: The weight data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Height

Height data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of cm

Time frame: The height data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.

Urinary glucose

Urinary glucose data were obtained by Urine routine data recorded in the diagnosis and treatment system, with unit of mmol/L.

Time frame: The urinary glucose data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure.