Resistance Exercise in Severe Knee Osteoarthritis

University of Valencia28 enrolled

Overview

This study aim to evaluate pain after different resistance training protocols (placebo, 4 sets of 10RM, 8 sets of 10 RM and 12 sets of 10RM) in patients with severe knee osteoarthritis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Knee Osteoarthritis

Interventions

Resistance ExerciseOTHER

10 Repetition Maximum (RM)

PlaceboOTHER

No exercise

Eligibility

Sex: ALLMin age: 55 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * men and women at least 55 years old * diagnosed with severe knee OA * scheduled for unilateral Total Knee Arthroplasty (TKA) surgery Exclusion Criteria: * pain in the contralateral (non-studied) limb (maximum ≥80 of 100 mm on a visual analog scale (VAS) during daily activities) * another hip or knee joint replacement in the previous year * any medical condition in which exercise was contraindicated * participated in exercise programs (\>2 days/week, training at intensities of 10-15RM) in the 6 months prior to the study * history of stroke, brain surgery, major depression, or any self-perceived cognitive alterations that could affect the performance of study tasks

Locations (1)

Clinic Universitary Hospital of Valencia

Valencia, Spain

Outcomes

Primary Outcomes

Change in self-reported pain intensity

Measure of knee pain intensity with the Visual Analogue Scale (0-100mm), with higher scores reflecting higher perceived pain intensity

Time frame: Pre-exercise (pre), immediate post exercise (post), and 10 min after exercise (post 10min)

Change in pressure pain thresholds

Measured with a mechanical algometer (Wagner Instruments, Greenwich, CT, USA) in three sites (vastus medialis of the affected limb, vastus medialis of the unaffected limb, and distal to the non-dominant arm lateral epicondyle)

Time frame: Pre-exercise (pre), immediate post exercise (post), and 10 min after exercise (post 10min)

Secondary Outcomes

WOMAC questionaire

A self-administered questionnaire for patients with hip or knee osteoarthritis. contain 24 items grouped into three dimensions: pain (5 items), stiffness (2 items) and physical function (17 items). Higher scores on the WOMAC indicate worse pain, stiffness, and functional limitations.

Time frame: pre-exercise

Tampa Scale of Kinesiophobia (TSK 11)

Measure fear of movement and its score ranges from 11-44 with higher scores indicate an increasing degree of kinesiophobia

Time frame: pre-exercise

Chronic Pain Self-Efficacy Scale

Measures three domains of pain self-efficacy: pain management, physical functioning, and coping with symptoms management, physical functioning, and coping with symptomsmanagement, physical functioning, and coping with symptoms. A higher score suggests higher self-efficacy

Time frame: pre-exercise

Pain Catastrophizing Scale

People are asked to indicate the degree to which they have certain thoughts and feelings when they are experiencing pain using the 0 (not at all) to 4 (all the time) scale. A total score is yielded (ranging from 0-52), along with three subscale scores assessing rumination, magnification and helplessness, with higher scores reflecting worse condition.

Data from ClinicalTrials.gov

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