The goal of this study is to learn what happens to MK-6552 in a person's body over time. Researchers will compare what happens to levels of MK-6552 in people's blood when it is taken with and without modafinil. Researchers also want to learn about the safety of MK-6552 taken with and without modafinil and if people tolerate it.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
Alliance for Multispecialty Research, LLC (Site 0001)
Knoxville, Tennessee, United States
Number of Participants Who Experience an Adverse Event (AE)
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
Time frame: Up to approximately 1 month
Number of Participants Who Discontinue Study Treatment Due to an AE
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
Time frame: Up to approximately 19 days
High Dose Modafinil Effect: Area Under the Concentration-Time Curve from Time 0 to Infinity (AUC0-inf) of MK-6552
Blood samples will be collected to determine the AUC0-inf of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
High Dose Modafinil Effect: Area Under the Concentration-Time Curve from Time 0 to 24 hours (AUC0-24hrs) of MK-6552
Blood samples will be collected to determine the AUC0-24hrs of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 24 hours postdose)
High Dose Modafinil Effect: Time to Maximum Plasma Concentration (Tmax) of MK-6552
Blood samples will be collected to determine the Tmax of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
High Dose Modafinil Effect: Maximum Plasma Concentration (Cmax) of MK-6552
Blood samples will be collected to determine the Cmax of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
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High Dose Modafinil Effect: Plasma Concentration of MK-6552 at 6 Hours Postdose (C6hrs)
Blood samples will be collected to determine the C6hrs of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 6 hours postdose)
High Dose Modafinil Effect: Plasma Concentration of MK-6552 at 8 Hours Postdose (C8hrs)
Blood samples will be collected to determine the C8hrs of MK-6552 in the presence of high dose modafinil
Time frame: At designated timepoints (up to approximately 8 hours postdose)
High Dose Modafinil Effect: Apparent Clearance (CL/F) of MK-6552
Blood samples will be collected to determine the CL/F of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
High Dose Modafinil Effect: Apparent Volume of Distribution During Terminal Phase (Vz/F) of MK-6552
Blood samples will be collected to determine the Vz/F of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
High Dose Modafinil Effect: Apparent Terminal Half-life (t1/2) of MK-6552
Blood samples will be collected to determine the t1/2 of MK-6552 in the presence of high dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
Low Dose Modafinil Effect: AUC0-inf of MK-6552
Blood samples will be collected to determine the AUC0-inf of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
Low Dose Modafinil Effect: AUC0-24hrs of MK-6552
Blood samples will be collected to determine the AUC0-24hrs of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 24 hours postdose)
Low Dose Modafinil Effect: Tmax of MK-6552
Blood samples will be collected to determine the Tmax of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
Low Dose Modafinil Effect: Cmax of MK-6552
Blood samples will be collected to determine the Cmax of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
Low Dose Modafinil Effect: C6hrs of MK-6552
Blood samples will be collected to determine the C6hrs of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 6 hours postdose)
Low Dose Modafinil Effect: C8hrs of MK-6552
Blood samples will be collected to determine the C8hrs of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 8 hours postdose)
Low Dose Modafinil Effect: CL/F of MK-6552
Blood samples will be collected to determine the CL/F of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
Low Dose Modafinil Effect: Vz/F of MK-6552
Blood samples will be collected to determine the Vz/F of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)
Low Dose Modafinil Effect: t1/2 of MK-6552
Blood samples will be collected to determine the t1/2 of MK-6552 in the presence of low dose modafinil.
Time frame: At designated timepoints (up to approximately 36 hours postdose)