This is a pilot study assessing the effects of combining a modified Atkins diet with a physical fitness regimen in patients with malignant glioma. A sample size of 15 participants will be enrolled in a 15-week program consisting of two weekly supervised exercise sessions combined with an individualized home exercise program and a modified Atkins diet.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
15
The Atkins diet is a low-carb eating plan that focuses on balancing protein, fat, and carbohydrates.
12 weeks of two weekly supervised exercise sessions combined with an individualized home exercise program based on physical capabilities and available equipment.
NYU Langone Health
New York, New York, United States
RECRUITINGChange in Short Form (SF)-36 Version 2 Score
The SF-36
Time frame: Baseline, Week 12
Number of Participants who Complete Full 12-Week Program
Time frame: Week 12
Change in Blood Ketone Levels
Time frame: Baseline, Week 12
Change in Resting Heart Rate
Time frame: Baseline, Week 12
Change in 400-meter Walk Time
Time to complete 400-meter-long distance corridor walk.
Time frame: Baseline, Week 12
Change in 1 Repetition Maximum (1RM) - Chest Press
The 1RM for chest press is the maximum weight an individual can perform for a chest press for one repetition.
Time frame: Baseline, Week 12
Change in 1 Repetition Maximum (1RM) - Leg Press
The 1RM for chest press is the maximum weight an individual can perform for a leg press for one repetition.
Time frame: Baseline, Week 12
Change in Satisfaction With Life Scale (SWLS) Score
5-item assessment of satisfaction with life. Each item is rated on a 7-point Likert scale. The total score is the sum of responses and ranges from 5-35; higher scores indicate greater satisfaction.
Time frame: Baseline, Week 12
Change in Hospital Anxiety And Depression Scale (HADS) - Anxiety Subscale Score
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The HADS is a self-report rating scale of 14 items on a 4-point Likert scale (range 0-3). It is designed to measure anxiety and depression (7 items for each subscale). The total score for the Anxiety subscale is the sum of the respective seven items. The total score ranges from 0-21; higher scores indicate greater anxiety.
Time frame: Baseline, Week 12
Change in Hospital Anxiety And Depression Scale (HADS) Score
The HADS is a self-report rating scale of 14 items on a 4-point Likert scale (range 0-3). It is designed to measure anxiety and depression (7 items for each subscale). The total score is the sum of the items; the total score ranges from 0-42; higher scores indicate greater anxiety and depression.
Time frame: Baseline, Week 12
Change in Fatigue Severity Scale (FSS) Score
The Fatigue Severity Scale (FSS) is a 9-item questionnaire that measures the severity of fatigue and how it affects a person's lifestyle and activities. Items are rated on a 7-point Likert scale. The total score is the sum of responses and ranges from 9 to 63. A higher score indicates greater fatigue severity.
Time frame: Baseline, Week 12